GNH USA

Europe — EMA

Isoprenalin Macure

GNH USA supplies Isoprenalin Macure (Isoprenaline), a beta‑adrenergic agonist for bradyarrhythmias and acute bronchospasm. Request a quote for global supply.

Isoprenaline Hydrochloride

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What is Isoprenaline Hydrochloride?

Isoprenaline, the active ingredient in Isoprenalin Macure, is a beta‑adrenergic agonist (non‑selective) presented as a sterile intravenous solution for rapid cardiovascular and respiratory support. It is employed to treat symptomatic bradyarrhythmias and to provide immediate bronchodilation in acute asthma or bronchospasm.

GNH USA supplies Isoprenalin Macure as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies, clinics and other healthcare facilities worldwide.

What is Isoprenaline Hydrochloride used for?

Isoprenalin acts on the cardiovascular and respiratory systems to correct abnormal heart rhythms and relieve severe airway constriction.

- Symptomatic sinus bradycardia: restores heart rate and improves cardiac output. - Acute heart block: enhances atrioventricular conduction to stabilize rhythm. - Severe asthma or bronchospasm: relaxes bronchial smooth muscle for rapid airway opening.

What are the side effects of Isoprenaline Hydrochloride?

Isoprenalin may produce a range of adverse reactions, varying from mild to potentially life‑threatening.

Common Side Effects: - Tachycardia - Palpitations - Tremor - Headache

Serious or Rare Side Effects: - Life‑threatening arrhythmias - Myocardial ischemia - Severe hypotension

What precautions apply to Isoprenaline Hydrochloride?

When using Isoprenalin, careful clinical monitoring and specific precautions are required to minimise risk. - Cardiac monitoring: continuously observe heart rate and rhythm. - Dose titration: adjust infusion based on hemodynamic response. - Contraindications: avoid in patients with uncontrolled tachyarrhythmias. - Caution in asthma: monitor for paradoxical bronchospasm. - Drug interactions: review concomitant beta‑blocker therapy. - Store at ambient temperature: keep in original container, protect from light and moisture.

What does Isoprenaline Hydrochloride interact with?

Isoprenalin can interact with several drug classes, influencing its efficacy and safety profile.

Major Interactions (Avoid): - Non‑selective beta‑blockers: antagonize therapeutic effect. - Class I antiarrhythmics (e.g., quinidine): increase risk of arrhythmias. - Tricyclic antidepressants: may exacerbate tachycardia.

Moderate Interactions (Monitor Closely): - Calcium channel blockers: additive cardiovascular depression. - Diuretics: potential electrolyte disturbances affecting response. - MAO inhibitors: possible hypertensive episodes.

Frequently asked questions

What is Isoprenalin Macure used for?+
Isoprenalin Macure is used in acute medical settings to treat symptomatic bradyarrhythmias such as sinus bradycardia and certain heart blocks, and to provide rapid bronchodilation in severe asthma or bronchospasm. It is administered intravenously under professional supervision.
How does Isoprenaline work?+
Isoprenaline is a non‑selective β1 and β2 adrenergic receptor agonist. By binding to these receptors it stimulates adenylate cyclase, raising intracellular cAMP, which increases heart rate and contractility via β1 and relaxes bronchial smooth muscle via β2, producing cardiovascular stimulation and bronchodilation.
What is the usual dose of Isoprenalin Macure?+
The dose is individualized by the prescribing clinician based on the patient’s condition, response, and monitoring parameters. Dosage regimens are determined in a hospital or clinical setting and are not standardized in public literature.
Is Isoprenalin Macure safe in pregnancy or breastfeeding?+
Safety data in pregnancy and lactation are limited. The drug should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.
How do I order Isoprenalin Macure from GNH USA?+
Submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Isoprenalin compare with other bronchodilators?+
Unlike selective β2 agonists such as albuterol, isoprenaline stimulates both β1 and β2 receptors, offering simultaneous cardiac stimulation and bronchodilation. This makes it useful in emergencies where both heart rate support and airway opening are needed, but it also carries a higher risk of cardiac side effects compared with β2‑selective agents.
How should Isoprenalin Macure be stored?+
Store at ambient temperature, below 25 °C, in the original sealed container. Protect from light, moisture and extreme temperature fluctuations. Do not freeze the solution. Follow any additional handling instructions provided with the product.
How is Isoprenalin Macure administered?+
The product is supplied as a sterile solution for intravenous injection. It is administered by a qualified healthcare professional, typically as a continuous infusion or intermittent bolus, with dosage titrated to achieve the desired heart rate or bronchodilation while monitoring vital signs.
What are the most serious risks associated with Isoprenalin?+
Serious adverse events include life‑threatening arrhythmias, myocardial ischemia, severe hypotension, pulmonary edema, and anaphylactic reactions. Continuous cardiac and hemodynamic monitoring is essential during administration to detect and manage these risks promptly.
Who should not use Isoprenalin Macure?+
Patients with known hypersensitivity to isoprenaline or any formulation components, those with uncontrolled tachyarrhythmias, severe hypertension, or recent myocardial infarction should avoid its use. Contra‑indications are determined by the treating physician based on individual clinical assessment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Isoprenaline Hydrochloride
Route
Intravenous Use
Manufacturer
Macure Pharma Aps
Origin
EU

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