GNH USA

Europe — EMA

Isoprenaline Macure

GNH USA supplies Isoprenaline Macure (Isoprenaline), a beta‑adrenergic agonist for bradycardia, heart block and asthma bronchospasm.

Isoprenaline Hydrochloride

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What is Isoprenaline Hydrochloride?

Isoprenaline, the active ingredient in Isoprenaline Macure, is a beta‑adrenergic agonist presented as an injectable solution for intravenous use. It is employed to increase heart rate and contractility in bradycardia and to relieve bronchospasm in asthma. GNH USA supplies Isoprenaline Macure as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Isoprenaline Hydrochloride used for?

Isoprenaline acts on the beta‑adrenergic system to treat conditions characterized by slow heart rhythm or bronchoconstriction. - Bradycardia: raises heart rate and improves cardiac output. - Heart block: enhances conduction through the atrioventricular node. - Asthma: relaxes airway smooth muscle to ease breathing. - Bronchospasm: provides rapid bronchodilation during acute episodes.

What are the side effects of Isoprenaline Hydrochloride?

Isoprenaline may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects: - Tachycardia: rapid heart rate exceeding therapeutic goals. - Palpitations: awareness of irregular heartbeat. - Tremor: fine shaking of hands or limbs. - Headache: mild to moderate intensity. - Nausea: occasional upset stomach. - Flushing: transient redness of skin.

Serious or Rare Side Effects: - Arrhythmias: potentially life‑threatening irregular rhythms. - Myocardial ischemia: reduced blood flow to heart muscle. - Severe hypotension: dangerous drop in blood pressure. - Pulmonary edema: fluid accumulation in lungs. - Anaphylactic reaction: acute allergic response requiring immediate care.

What precautions apply to Isoprenaline Hydrochloride?

Careful assessment and monitoring are essential when using Isoprenaline. - Cardiac monitoring: continuous ECG and blood pressure checks during infusion. - Hypertension caution: avoid rapid dose escalation in patients with high blood pressure. - Recent myocardial infarction: use only if benefits outweigh risks. - Hyperthyroidism: monitor for exaggerated cardiac response. - Severe aortic stenosis: contraindicated due to risk of obstruction. - Store at room temperature: keep in original container, protect from moisture and light.

What does Isoprenaline Hydrochloride interact with?

Isoprenaline can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid): - Non‑selective beta‑blockers (e.g., propranolol): antagonize therapeutic effects. - MAO inhibitors: may potentiate cardiovascular stimulation. - Calcium channel blockers (e.g., verapamil): increase risk of severe hypotension.

Moderate Interactions (Monitor Closely): - Digoxin: may enhance arrhythmic potential. - Diuretics: can exacerbate electrolyte disturbances. - Antihypertensive agents: require dose adjustments to avoid excessive blood pressure fall. - Anesthetic agents: may intensify cardiovascular responses during surgery.

Frequently asked questions

What is Isoprenaline Macure used for?+
Isoprenaline Macure is an injectable beta‑adrenergic agonist used primarily to treat symptomatic bradycardia, various forms of heart block, and acute bronchospasm associated with asthma. By stimulating β1 receptors it raises heart rate and contractility, while β2 activation relaxes airway smooth muscle, providing rapid relief of breathing difficulties.
How does Isoprenaline work?+
The drug binds to both β1 and β2 adrenergic receptors. In the heart, β1 activation raises cyclic AMP levels, increasing calcium entry into cardiac cells, which speeds up pacemaker activity and strengthens contraction. In the lungs, β2 stimulation raises cyclic AMP in airway smooth muscle, causing relaxation and bronchodilation.
What is the usual dose of Isoprenaline Macure?+
Dosing is individualized and must be determined by a qualified prescriber based on the patient’s clinical condition, weight, and response. The healthcare professional will set the infusion rate, titrate as needed, and monitor vital signs to achieve the desired therapeutic effect while minimizing adverse reactions.
Is Isoprenaline safe during pregnancy or breastfeeding?+
Safety data for Isoprenaline in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.
How do I order Isoprenaline Macure from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.
How does Isoprenaline compare with other cardiac stimulants?+
Isoprenaline differs from agents such as dopamine or epinephrine by providing strong β‑adrenergic stimulation with relatively less α‑mediated vasoconstriction. This results in pronounced heart‑rate acceleration and bronchodilation but may cause fewer increases in systemic vascular resistance compared with epinephrine. Choice of agent depends on the specific clinical scenario and physician judgment.
What are the storage and handling requirements for Isoprenaline Macure?+
The product should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not freeze the solution. Before use, inspect the vial for particulate matter or discoloration and discard if any abnormalities are observed.
How is Isoprenaline administered?+
Isoprenaline is given intravenously, typically as a controlled infusion. The medication is diluted in an appropriate carrier solution according to the prescriber’s instructions and administered via a calibrated infusion pump or syringe driver, allowing precise titration to achieve the desired hemodynamic or bronchodilatory response.
What are the most serious risks associated with Isoprenaline?+
Serious adverse events include life‑threatening arrhythmias, myocardial ischemia, severe hypotension, pulmonary edema, and anaphylactic reactions. Patients should be continuously monitored for changes in heart rhythm, blood pressure, and respiratory status, and immediate medical intervention should be available if any of these complications arise.
Who should not use Isoprenaline?+
Isoprenaline is contraindicated in patients with severe aortic stenosis, uncontrolled hypertension, recent myocardial infarction, or known hypersensitivity to the drug or its excipients. Caution is also advised in individuals with hyperthyroidism, severe heart failure, or those taking non‑selective beta‑blockers, as the therapeutic effect may be blunted.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Isoprenaline Hydrochloride
Route
Intravenous Use
Manufacturer
Macure Pharma Aps
Origin
EU

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