Iodopol (Sodium Iodide (131i))

Sodium Iodide, the active ingredient in Iodopol, is a Radioactive iodine presented as an oral preparation for oral use. It is employed in the treatment of thyroid cancer, hyperthyroidism and for thyroid ablation in patients requiring reduction of thyroid tissue activity. GNH USA supplies Iodopol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Iodopol delivers radioactive iodine to thyroid tissue, making it useful for several thyroid‑related conditions. - Thyroid cancer: facilitates targeted destruction of malignant thyroid cells. - Hyperthyroidism: reduces excess hormone production by ablating overactive thyroid tissue. - Thyroid ablation: prepares patients for subsequent thyroid hormone replacement by eliminating residual thyroid tissue.

Iodopol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild gastrointestinal upset after ingestion. - Dry mouth: reduced salivary flow. - Neck tenderness: localized discomfort in the thyroid region. - Fatigue: transient feeling of tiredness. - Transient hypothyroidism: temporary reduction in thyroid hormone levels.

Serious or Rare Side Effects: - Radiation thyroiditis: painful inflammation of the thyroid gland. - Salivary gland dysfunction: persistent dry mouth or swelling. - Bone marrow suppression: decreased blood cell counts. - Secondary malignancies: rare risk of other cancers due to radiation exposure. - Allergic reaction: rash, itching, or swelling at the site of administration.

Before prescribing Iodopol, clinicians should consider several safety measures. - Pregnancy: avoid use unless clearly needed, as fetal thyroid can be affected. - Breastfeeding: discontinue breastfeeding during treatment and for a period afterward. - Renal impairment: adjust dose or monitor closely due to altered iodine clearance. - Pre‑existing thyroiditis: assess risk of exacerbated inflammation. - Concomitant radiation therapy: coordinate to prevent overlapping radiation doses. Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Iodopol can interact with other medications, influencing its efficacy or safety.

Major Interactions (Avoid): - Antithyroid drugs (e.g., methimazole, propylthiouracil): may reduce iodine uptake. - Lithium: can impair thyroid hormone release and alter treatment response.

Moderate Interactions (Monitor Closely): - Amiodarone: high iodine content may affect thyroid function. - Corticosteroids: may lessen radiation‑induced thyroiditis but require monitoring. - Diuretics: can alter renal iodine excretion, affecting dosing considerations.