Iodopol

Sodium Iodide, the active ingredient in Iodopol, is a radioactive iodine presented as a radiopharmaceutical for oral use. It is employed in the management of thyroid cancer, hyperthyroidism ablation, and thyroid imaging in adult patients. GNH USA supplies Iodopol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Iodopol is used in the radioactive iodine pathway to diagnose and treat thyroid‑related conditions. - Thyroid cancer treatment: delivers targeted beta radiation to destroy malignant thyroid tissue. - Hyperthyroidism (thyroid ablation): ablates overactive thyroid cells to restore normal hormone levels. - Thyroid imaging and diagnostic scans: provides gamma emission for high‑resolution scintigraphy and whole‑body scans.

Adverse reactions may occur following oral administration of radioactive iodine.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Dry mouth: reduced salivary flow. - Taste alteration: metallic or bitter sensation. - Transient thyroid pain: mild discomfort in the neck region. - Mild leukopenia: temporary reduction in white blood cells. - Fatigue: short‑term tiredness.

Serious or Rare Side Effects: - Severe radiation thyroiditis: intense inflammation of the thyroid gland. - Bone marrow suppression: prolonged pancytopenia requiring monitoring. - Allergic reaction: rash, pruritus, or anaphylaxis in rare cases. - Pulmonary fibrosis: rare radiation‑induced lung injury. - Secondary malignancy: potential long‑term risk of new cancers. - Salivary gland dysfunction: persistent xerostomia.

Prior assessment and ongoing monitoring are essential when using Iodopol. - Baseline thyroid function: obtain serum TSH, T3, and T4 before therapy. - Blood count monitoring: perform complete blood counts during and after treatment. - Pregnancy avoidance: do not administer to pregnant women unless benefits outweigh risks. - Lactation caution: advise breastfeeding cessation during therapy. - Concomitant medication review: evaluate for drugs that affect iodine uptake. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Iodopol may interact with other agents that influence thyroid function or radiation response.

Major Interactions (Avoid): - Lithium: potentiates thyroid dysfunction and may alter iodine uptake. - Antithyroid drugs (e.g., methimazole, propylthiouracil): reduce therapeutic efficacy. - Amiodarone: high iodine content interferes with radioiodine distribution.

Moderate Interactions (Monitor Closely): - Levothyroxine: adjust dose based on thyroid function tests. - Anticoagulants (e.g., warfarin): monitor INR for radiation‑induced changes. - Diuretics: assess electrolyte balance during therapy. - Beta‑blockers: may mask symptoms of thyroid storm.