GNH USA

Europe — EMA

Insulatard Innolet

GNH USA supplies Insulatard Innolet (Insulin Human), a insulin for type 1 and type 2 diabetes mellitus.

Insulin Human

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What is Insulin Human?

Insulin human, the active ingredient in Insulatard Innolet, is an insulin presented as a 100 IU/mL solution for injection for subcutaneous use. It treats diabetes mellitus in both type 1 and type 2 patients.

GNH USA supplies Insulatard Innolet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Insulin Human used for?

Insulatard Innolet, a long‑acting insulin, is used to manage blood glucose in diabetes mellitus.

- Type 1 diabetes mellitus: provides basal insulin coverage to maintain fasting glucose levels. - Type 2 diabetes mellitus: complements oral agents or rapid‑acting insulin to achieve overall glycaemic control. - Hospitalised hyperglycaemia: supplies basal insulin for patients requiring stable glucose management during inpatient care.

What are the side effects of Insulin Human?

Common Side Effects: - Hypoglycaemia: low blood glucose episodes, especially if meals are missed or dosing is excessive. - Injection site reactions: redness, swelling, or itching at the injection site. - Weight gain: modest increase due to improved glucose utilisation. - Lipodystrophy: localized changes in subcutaneous fat with repeated injections.

Serious or Rare Side Effects: - Severe hypoglycaemia with seizures or loss of consciousness. - Anaphylactic reaction: systemic allergic response requiring immediate medical attention. - Insulin antibodies: may alter insulin efficacy or cause hypersensitivity. - Stevens‑Johnson syndrome or toxic epidermal necrolysis: rare severe skin reactions. - Acute metabolic acidosis: very rare but potentially life‑threatening.

What precautions apply to Insulin Human?

Before using Insulatard Innolet, consider the following precautions: - Dose adjustment: modify the dose in renal or hepatic impairment to avoid hypoglycaemia. - Blood‑glucose monitoring: check glucose levels frequently, especially when initiating therapy. - Hypoglycaemia unawareness: use caution in patients who cannot recognise low‑glucose symptoms. - Pregnancy and lactation: safety category is unknown; weigh benefits against potential risks. - Concomitant medications: review drugs that may potentiate or mask hypoglycaemia. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

What does Insulin Human interact with?

Insulatard Innolet may interact with other medicines as follows:

Major Interactions (Avoid): - Sulfonylureas or meglitinides: combined use can cause severe hypoglycaemia. - Alcohol: may potentiate insulin’s glucose‑lowering effect and increase hypoglycaemia risk. - Beta‑blockers: can mask typical hypoglycaemia symptoms such as tachycardia.

Moderate Interactions (Monitor Closely): - Corticosteroids: may raise blood glucose, requiring insulin dose adjustments. - Thyroid hormones: can alter insulin requirements, necessitating close monitoring. - Diuretics (especially thiazides): may affect potassium levels and insulin sensitivity. - ACE inhibitors or ARBs: may influence potassium balance and require periodic checks.

Frequently asked questions

What is Insulatard Innolet used for?+
Insulatard Innolet is a long‑acting insulin formulation used to provide basal insulin coverage in patients with type 1 or type 2 diabetes mellitus. It helps maintain stable fasting blood‑glucose levels and is often combined with rapid‑acting insulins or oral antidiabetic agents for comprehensive glycaemic control.
How does insulin human work in the body?+
Insulin human binds to insulin receptors on muscle, fat and liver cells, activating intracellular pathways that promote glucose uptake, glycogen synthesis and lipid storage while suppressing hepatic glucose production. The NPH (neutral protamine Hagedorn) component slows absorption, extending the insulin’s action to provide a basal effect for many hours after injection.
What is the usual dose of Insulatard Innolet?+
The dose of Insulatard Innolet is individualized and set by a qualified prescriber based on the patient’s blood‑glucose targets, body weight, diet, activity level and concurrent therapies. Patients should follow the dosing instructions provided by their healthcare professional and adjust only under medical supervision.
Is Insulatard Innolet safe during pregnancy or breastfeeding?+
The pregnancy safety category for insulin human (NPH) is not definitively established. Insulin is generally considered the preferred glucose‑lowering therapy in pregnancy when needed, but the decision should be made by the treating obstetrician and endocrinologist after weighing potential benefits and risks. Breastfeeding mothers should also consult their physician.
How do I order Insulatard Innolet from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity of Insulatard Innolet. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics) and any necessary import documentation.
How does Insulatard Innolet compare with other basal insulins?+
Insulatard Innolet (NPH insulin) is a protamine‑combined formulation that offers a peak of action around 4‑12 hours and a duration of up to 18 hours, making it suitable for twice‑daily dosing. Compared with newer basal analogues such as glargine or degludec, NPH has a more pronounced peak and may require more frequent glucose monitoring, but it is often less expensive and widely available.
What are the storage and handling requirements for Insulatard Innolet?+
Insulatard Innolet should be stored in a refrigerator at 2‑8 °C, protected from light and kept in its original packaging. Do not freeze the product, and avoid shaking the vial. Once in use, the solution can be kept at room temperature (up to 25 °C) for a maximum of 28 days, after which any remaining product should be discarded.
How is Insulatard Innolet administered?+
Insulatard Innolet is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection site should be rotated with each dose to reduce the risk of lipodystrophy. Patients should be trained by a healthcare professional on proper injection technique, needle length selection and disposal of used sharps.
What are the most serious risks associated with Insulatard Innolet?+
The most serious risks include severe hypoglycaemia, which can lead to seizures, loss of consciousness or even death if not promptly treated, and rare allergic reactions such as anaphylaxis. Patients should be educated on recognising early signs of low blood glucose and have a rapid‑acting carbohydrate source readily available.
Who should not use Insulatard Innolet?+
Insulatard Innolet should be avoided in individuals with a known hypersensitivity to insulin human, protamine or any excipients in the formulation. It is also contraindicated in patients with severe hypoglycaemia unawareness or those who cannot reliably monitor their blood glucose levels. Clinical judgment is required for patients with significant renal or hepatic impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Insulin Human
Route
Subcutaneous Use
Manufacturer
Novo Nordisk A/S
Origin
EU

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