Humulin R 100 [iU]/mL

Insulin human, the active ingredient in Humulin R 100 [iU]/mL, is an insulin presented as a 100 IU/mL/injection solution for parenteral use. It is used to help manage type 1 diabetes mellitus and type 2 diabetes mellitus in patients who require insulin therapy.

GNH USA supplies Humulin R 100 [iU]/mL as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Humulin R contains insulin human, a short-acting insulin used in the management of diabetes mellitus and related hyperglycemia.

- Type 1 diabetes mellitus: provides exogenous insulin when the body does not produce enough on its own. - Type 2 diabetes mellitus: helps improve glycemic control when insulin treatment is required. - Hyperglycemia requiring insulin therapy: supports blood glucose reduction under clinician supervision in patients prescribed insulin.

Humulin R can cause adverse reactions related to insulin therapy and injection use.

Common Side Effects: - Hypoglycemia: the most common and clinically important adverse effect. - Injection-site reactions: redness, swelling, itching, or discomfort may occur. - Weight gain: may be seen during insulin treatment. - Lipodystrophy: repeated injections in the same area can change local fat tissue.

Serious or Rare Side Effects: - Severe hypoglycemia: can cause confusion, seizure, loss of consciousness, or need for urgent treatment. - Hypokalemia: insulin can lower serum potassium. - Severe allergic reaction: rare but potentially life-threatening hypersensitivity may occur.

Humulin R requires careful use because insulin therapy can cause clinically significant adverse effects.

- Monitor glucose: blood sugar monitoring helps detect hypoglycemia or inadequate control. - Watch for hypoglycemia: risk increases if meals are delayed, missed, or intake changes. - Use caution with dose changes: adjustments may be needed with illness, activity, or changes in diet. - Rotate injection sites: repeated use of one site can contribute to lipodystrophy. - Check for allergy: discontinue and seek urgent care if signs of serious hypersensitivity occur. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Humulin R may interact with other medicines that increase or decrease its glucose-lowering effect.

Major Interactions (Avoid): - Other glucose-lowering agents: combined use can increase hypoglycemia risk and requires clinician oversight. - Alcohol: may worsen or prolong hypoglycemia.

Moderate Interactions (Monitor Closely): - Beta-blockers: can mask warning signs of hypoglycemia. - Corticosteroids: may reduce insulin effect and increase glucose. - Diuretics: some can affect glucose control or potassium balance. - ACE inhibitors: may enhance insulin sensitivity in some patients.