Humulin R U-500 500 [iU]/mL

Insulin human, the active ingredient in Humulin R U-500, is a short-acting insulin presented as a 500 [iU]/mL injection solution for subcutaneous use. It is used to manage diabetes mellitus in patients requiring high insulin doses, including those with type 1 or type 2 diabetes. GNH USA supplies Humulin R U-500 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Humulin R U-500 is specifically designed for patients who need more than 200 units of insulin per day. It is available in a concentrated form to facilitate easier administration for those with significant insulin requirements.

Humulin R U-500 is a short-acting insulin used to manage diabetes mellitus, particularly in patients with high insulin requirements. It is indicated for the following conditions:

- Type 1 diabetes mellitus: Helps manage blood glucose levels in patients who require insulin due to insufficient insulin production. - Type 2 diabetes mellitus (high insulin requirements): Used in patients who need more than 200 units of insulin per day to control their blood sugar levels. - Diabetes management in patients with significant insulin resistance: Assists in achieving glycemic control in individuals who do not respond adequately to lower concentrations of insulin.

Humulin R U-500, like other insulin products, can cause various side effects. Common Side Effects: - Hypoglycemia: Low blood sugar levels, which can cause symptoms such as sweating, dizziness, and confusion. - Injection site reactions: Redness, swelling, or itching at the injection site. - Weight gain: Increased body weight due to improved glucose utilization and storage. - Peripheral edema: Swelling in the extremities due to fluid retention.

Serious or Rare Side Effects: - Hypokalemia: Low potassium levels, which can lead to muscle weakness and irregular heartbeat. - Lipodystrophy: Changes in fat distribution at the injection site, which can affect insulin absorption. - Allergic reactions: Severe allergic responses, including anaphylaxis, which require immediate medical attention. - Hypersensitivity reactions: Allergic reactions that can manifest as rash, itching, or difficulty breathing.

Humulin R U-500 should be used with caution and under medical supervision. Important precautions include: - Monitor blood glucose levels regularly: Frequent monitoring is essential to avoid hypoglycemia or hyperglycemia. - Adjust dosage as directed: Dosage adjustments should be made by a healthcare professional based on individual needs. - Avoid mixing with other insulins: Humulin R U-500 should not be mixed with other insulin products to prevent dosing errors. - Inform healthcare providers of all medications: Certain drugs can interact with Humulin R U-500, affecting its efficacy or safety. - Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Humulin R U-500 can interact with various medications, which may affect its efficacy or increase the risk of side effects. Major Interactions (Avoid): - Oral antidiabetic agents: Concurrent use can increase the risk of hypoglycemia. - Angiotensin-converting enzyme (ACE) inhibitors: May enhance the hypoglycemic effect of insulin. - Monoamine oxidase inhibitors (MAOIs): Can potentiate the hypoglycemic effect of insulin.

Moderate Interactions (Monitor Closely): - Beta-blockers: Can mask symptoms of hypoglycemia and interfere with glucose metabolism. - Corticosteroids: May reduce the hypoglycemic effect of insulin. - Thiazide diuretics: Can decrease insulin sensitivity and increase blood glucose levels.