GNH USA

Europe — EMA

Indium (In111) Oxinate Curium Netherlands (Indium (111in) Oxine)

GNH USA supplies Indium-111 Oxine (Indium-111 oxine), a diagnostic radiopharmaceutical for detection of infection, inflammation and abscess localization.

Indium (111in) Oxine

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What is Indium (111in) Oxine?

Indium-111 oxine, the active ingredient in Indium (In111) Oxinate Curium Netherlands, is a diagnostic radiopharmaceutical presented as a solution for injection for intravenous use. It provides a radioactive label that binds to leukocytes, enabling gamma‑camera visualization of infection and inflammation in patients. GNH USA supplies Indium (In111) Oxinate Curium Netherlands as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Indium (111in) Oxine used for?

Indium-111 oxine is used in nuclear medicine to image sites of infection and inflammation by labeling white blood cells. - Infection detection: highlights areas of bacterial infection for diagnostic clarification. - Inflammation assessment: visualizes inflammatory foci such as vasculitis or sarcoidosis. - Abscess localization: helps locate abscesses and guide surgical or interventional planning.

What are the side effects of Indium (111in) Oxine?

Adverse reactions are generally related to the radiopharmaceutical nature and injection process.

Common Side Effects: - Injection site pain: mild discomfort at the venipuncture site. - Transient fever: low‑grade temperature rise within hours. - Nausea: occasional mild nausea post‑administration. - Headache: brief headache reported by some patients.

Serious or Rare Side Effects: - Allergic reaction: urticaria, bronchospasm, or anaphylaxis. - Radiation‑induced tissue injury: rare, related to cumulative exposure. - Severe neutropenia: uncommon, monitor blood counts if indicated. - Hemolysis: very rare, may present with anemia signs.

What precautions apply to Indium (111in) Oxine?

Radiopharmaceuticals require specific safety and patient considerations. - Pregnancy: avoid unless essential, due to fetal radiation exposure. - Breastfeeding: discontinue breastfeeding for an appropriate interval after administration. - Renal function: assess kidney function as excretion is renal. - Radiation safety: follow institutional radiation protection protocols for staff and patients. - Allergy history: screen for prior hypersensitivity to indium compounds. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Indium (111in) Oxine interact with?

Radiopharmaceuticals may interact with other agents that affect leukocyte distribution or radiation dose.

Major Interactions (Avoid): - Concurrent high‑dose steroids: may suppress leukocyte migration, reducing image quality. - Other radiopharmaceuticals administered within 24 hours: can cause overlapping radiation fields.

Moderate Interactions (Monitor Closely): - Immunosuppressive therapy: may alter leukocyte kinetics, affecting imaging. - Chemotherapeutic agents: monitor for additive bone‑marrow suppression. - Anticoagulants: increased risk of bleeding at injection site.

Frequently asked questions

What is Indium-111 oxine used for?+
Indium-111 oxine is used in nuclear medicine to label white blood cells, allowing gamma‑camera imaging of infection, inflammation and abscesses. The technique helps clinicians locate and assess the extent of infectious or inflammatory processes in the body.
How does Indium-111 oxine work?+
The oxine component transports the radioactive Indium‑111 into leukocytes ex vivo, forming a stable complex. After the labeled cells are re‑injected, they migrate to sites of active infection or inflammation, where the emitted gamma photons are detected by imaging equipment, producing diagnostic images.
What is the usual dose of Indium-111 oxine?+
The administered activity is determined by the prescribing physician based on the patient’s weight, clinical indication and imaging protocol. Dosing is individualized and should follow the radiopharmacy’s preparation guidelines and local regulatory requirements.
Is Indium-111 oxine safe during pregnancy or breastfeeding?+
Indium-111 oxine is classified as a radiopharmaceutical with potential fetal radiation exposure, so it is generally avoided in pregnancy unless the diagnostic benefit outweighs the risk. Breastfeeding should be paused for an appropriate period after administration to prevent infant radiation exposure.
How do I order Indium (In111) Oxinate Curium Netherlands from GNH USA?+
Submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.
How does Indium-111 oxine compare with other infection‑imaging agents?+
Indium-111 oxine is a well‑established leukocyte‑labeling agent offering high specificity for infection and inflammation. Compared with agents like Technetium‑99m HMPAO‑labeled leukocytes, Indium‑111 provides longer imaging windows due to its 2.8‑day half‑life, but involves higher radiation dose and requires gamma‑camera equipment capable of detecting its higher‑energy photons.
What are the storage and handling requirements for Indium-111 oxine?+
The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. It should be kept in the original container until use, and handled by trained personnel following radiation safety guidelines.
How is Indium-111 oxine administered?+
Indium-111 oxine is supplied as a sterile solution for injection. After leukocyte labeling in a radiopharmacy, the radiolabeled cells are administered intravenously under aseptic conditions, typically in a clinical setting equipped for radiopharmaceutical handling.
What are the most serious risks associated with Indium-111 oxine?+
Serious risks include allergic reactions ranging from urticaria to anaphylaxis, radiation‑induced tissue injury, and rare hematologic effects such as severe neutropenia or hemolysis. Patients should be monitored for immediate hypersensitivity and radiation safety protocols must be observed.
Who should not receive Indium-111 oxine?+
Patients with known hypersensitivity to indium compounds, pregnant women unless absolutely necessary, breastfeeding mothers, and individuals with severe renal impairment or uncontrolled infection where leukocyte migration may be compromised should avoid this radiopharmaceutical.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Indium (111in) Oxine
Route
Intravenous Use
Manufacturer
Curium Netherlands B.V.
Origin
EU

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