Europe — EMA
Vadyrano (Ivabradine)
Vadyrano (ivabradine) is an oral medication used to help lower heart rate in adults. It works by slowing electrical activity in the heart’s natural pacemaker. T
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What is Ivabradine?
Vadyrano (ivabradine) is an oral medication used to help lower heart rate in adults. It works by slowing electrical activity in the heart’s natural pacemaker. This eases the heart’s workload and supports healthy circulation.
What is Ivabradine used for?
Vadyrano is primarily used to reduce heart rate in adults with stable angina or chronic heart failure when standard treatments are unsuitable. It may also be considered for patients with elevated heart rates who need rhythm control. This medication helps improve exercise capacity and reduce symptoms like chest pain.
What are the side effects of Ivabradine?
Vadyrano works by selectively inhibiting the cardiac pacemaker current, which naturally slows the heart rate. Users may notice improved comfort during physical activity as the heart beats more efficiently. Some people experience mild visual effects, such as temporary brightness in the visual field, especially when changing light conditions.
What precautions apply to Ivabradine?
Vadyrano should be taken exactly as prescribed, usually twice daily with meals. It is important to avoid grapefruit and grapefruit juice while using this medication. Regular heart rate monitoring is recommended to ensure the dose remains appropriate. Patients should report any new or worsening symptoms to their healthcare provider promptly.
What does Ivabradine interact with?
Vadyrano may interact with medications that affect heart rhythm or are metabolized by the liver, such as certain calcium channel blockers or strong CYP3A4 inhibitors. Alcohol and other substances that lower heart rate should be used with caution. Always inform your healthcare provider about all prescription, over-the-counter, and herbal products you are taking.



