Lactated Ringer’s Injection Fresenius

Sodium lactate, the active ingredient in Lactated Ringer’s Injection, is an electrolyte solution presented as a 3 g/L sodium lactate injection solution for intravenous use. It restores extracellular fluid volume and corrects metabolic acidosis in patients requiring fluid resuscitation, peri‑operative care, or dehydration management.

GNH USA supplies Lactated Ringer’s Injection as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Lactated Ringer’s solution is used as an isotonic electrolyte fluid for volume expansion and electrolyte replacement.

- Fluid resuscitation: restores intravascular volume in hypovolemic patients. - Perioperative fluid management: maintains hemodynamic stability during surgery. - Treatment of dehydration: replaces lost fluids and electrolytes. - Correction of metabolic acidosis: provides lactate that is metabolized to bicarbonate. - Electrolyte replacement: supplies sodium, potassium, calcium, and chloride to correct imbalances.

Common Side Effects: - Mild hyperkalemia: slight increase in serum potassium. - Transient hypertension: temporary rise in blood pressure. - Local irritation: discomfort at the intravenous site. - Nausea: occasional feeling of nausea.

Serious or Rare Side Effects: - Fluid overload: risk of pulmonary edema in susceptible patients. - Severe hypernatremia: excessive sodium leading to neurologic symptoms. - Allergic reaction: anaphylaxis or severe hypersensitivity.

Lactated Ringer’s Injection should be administered with careful clinical assessment.

- Assess volume status: evaluate patient’s fluid balance before administration. - Monitor electrolytes: check serum sodium, potassium, and calcium levels during therapy. - Use caution in renal failure: adjust volume to avoid overload. - Avoid in severe heart failure: risk of exacerbating cardiac dysfunction. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Lactated Ringer’s Injection may interact with other medications affecting fluid and electrolyte balance.

Major Interactions (Avoid): - Concurrent hypertonic saline: may cause severe hypernatremia. - High-dose potassium supplements: risk of hyperkalemia. - Calcium channel blockers: can potentiate calcium load.

Moderate Interactions (Monitor Closely): - Diuretics: may alter electrolyte balance, requiring monitoring. - ACE inhibitors: can affect potassium levels. - NSAIDs: may impair renal function, increasing risk of fluid overload.