Natrium Citrát Grifols (Sodium Citrate)

Sodium citrate, the active ingredient in Natrium Citrát Grifols, is an anticoagulant presented as a sterile solution for extracorporeal use. It chelates calcium ions in collected blood, helping to prevent clot formation during procedures such as dialysis, apheresis, and blood component preparation. The product conforms to EU quality standards and is manufactured by Grifols.

GNH USA supplies Natrium Citrát Grifols as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide.

Sodium citrate is used as an anticoagulant in extracorporeal circuits and blood processing.

- Hemodialysis: maintains blood fluidity during treatment, reducing clot risk in the dialyzer. - Apheresis procedures: prevents clotting in collection lines while separating blood components. - Blood component preparation: preserves platelet function and plasma quality during storage and processing.

Sodium citrate may cause electrolyte and metabolic changes when used in extracorporeal settings.

Common Side Effects: - Hypocalcemia symptoms: tingling, muscle cramps, or paresthesia. - Transient metabolic alkalosis due to citrate metabolism. - Mild nausea or gastrointestinal discomfort.

Serious or Rare Side Effects: - Severe hypocalcemia leading to cardiac arrhythmia or hypotension. - Allergic reactions ranging from rash to anaphylaxis. - Bleeding complications if anticoagulation is excessive. - Severe metabolic disturbances in patients with impaired liver function. - Rare cases of citrate toxicity with prolonged exposure.

When using sodium citrate, careful monitoring and patient assessment are essential. - Assess calcium levels: monitor ionized calcium during and after infusion. - Adjust citrate infusion rate: tailor to individual metabolic status and procedure duration. - Avoid in patients with severe liver dysfunction: impaired citrate clearance can cause accumulation. - Use caution with calcium channel blocker therapy: may exacerbate hypocalcemia. - Store below 25°C: keep in the original pack, protect from moisture and light.

Sodium citrate can interact with other agents that affect calcium balance or electrolyte homeostasis.

Major Interactions (Avoid): - Calcium supplements: counteract the anticoagulant effect and may cause precipitation. - Magnesium sulfate: may enhance hypocalcemia and metabolic alkalosis. - High‑dose vitamin D: can interfere with calcium regulation during citrate therapy.

Moderate Interactions (Monitor Closely): - Loop diuretics: alter electrolyte excretion, requiring closer calcium monitoring. - Beta‑agonists: may increase the risk of citrate‑induced hypocalcemia. - Anticonvulsants such as phenytoin: can affect calcium metabolism and necessitate dose adjustments.