RYBELSUS 4 mg/1

Semaglutide, the active ingredient in RYBELSUS, is a GLP-1 receptor agonist presented as a 4 mg tablet for oral use. It is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

GNH USA supplies RYBELSUS as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

RYBELSUS is a GLP-1 receptor agonist used in the management of type 2 diabetes mellitus. It helps to lower blood sugar levels and reduce the risk of major cardiovascular events in adults with type 2 diabetes who are at high risk for these events.

- Type 2 Diabetes Mellitus: Improves glycemic control in adults when used alongside diet and exercise. - Cardiovascular Risk Reduction: Reduces the risk of major adverse cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes who are at high risk for these events.

RYBELSUS may cause various side effects, ranging from common to serious or rare. It is important to be aware of these potential effects when using the medication.

Common Side Effects: - Nausea - Vomiting - Diarrhea - Constipation - Abdominal pain - Decreased appetite

Serious or Rare Side Effects: - Pancreatitis - Hypoglycemia (low blood sugar) - Kidney problems - Allergic reactions - Changes in vision - Gallbladder problems

When using RYBELSUS, certain precautions and warnings should be considered to ensure safe and effective use. Always follow the advice of a healthcare professional.

- Administration: Must be taken at least 30 minutes before the first food, beverage, or other oral medications of the day with no more than 4 ounces of plain water. - Titration: Typically started at a lower dose to minimize gastrointestinal effects, then increased as needed. - Missed Dose: If a dose is missed, the skipped dose should be skipped entirely, and the next dose taken the following day. - Hypoglycemia: May occur when used with other diabetes medications, so blood sugar levels should be monitored closely. - Pancreatitis: Symptoms such as persistent severe abdominal pain should be reported immediately. - Store at room temperature: Keep in a dry place away from moisture and store tablets in the original closed bottle until ready to use.

RYBELSUS may interact with other medications, which can affect its efficacy or increase the risk of side effects. It is important to be aware of these potential interactions.

Major Interactions (Avoid): - Insulin: May increase the risk of hypoglycemia when used together. - Other GLP-1 receptor agonists: May increase the risk of gastrointestinal side effects. - Oral medications: May affect the absorption of other oral medications due to delayed gastric emptying.

Moderate Interactions (Monitor Closely): - Sulfonylureas: May increase the risk of hypoglycemia. - Diuretics: May affect blood pressure and fluid balance. - Corticosteroids: May affect blood sugar levels and require dose adjustments.