Paramed (Ibuprofen)

Ibuprofen, the active ingredient in Paramed, is a non‑steroidal anti‑inflammatory drug presented as a 200 mg tablet for oral use. It is commonly used to relieve pain, reduce fever, and diminish inflammation in adults and children.

GNH USA supplies Paramed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts on inflammatory pathways to provide analgesic and antipyretic effects. - Mild to moderate pain: alleviates headache, dental pain, musculoskeletal discomfort, and menstrual cramps. - Fever: lowers elevated body temperature associated with infections or inflammatory conditions. - Inflammatory disorders: reduces swelling and pain in conditions such as osteoarthritis and rheumatoid arthritis.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or mild abdominal pain. - Headache: transient headache episodes. - Dizziness: light‑headed feeling or vertigo. - Skin reactions: mild rash or itching. - Elevated blood pressure: modest increase in systolic/diastolic readings.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Severe skin reactions such as Stevens‑Johnson syndrome. - Renal impairment or acute kidney injury. - Anaphylaxis: rapid onset of hives, swelling, and airway compromise. - Hepatotoxicity: elevated liver enzymes or hepatitis.

When using Paramed, consider the following safety measures: - Assess renal function: evaluate baseline kidney health before initiating therapy. - Monitor gastrointestinal risk: avoid use in patients with a history of ulcers or bleeding. - Evaluate cardiovascular status: use cautiously in individuals with hypertension or heart disease. - Review concomitant medications: check for other NSAIDs or anticoagulants that may increase bleeding risk. - Pregnancy and lactation: limit use to the shortest duration necessary and only under medical supervision. - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ibuprofen may interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin: additive gastrointestinal toxicity. - Selective COX‑2 inhibitors (e.g., celecoxib): heightened cardiovascular risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function. - Diuretics (e.g., furosemide): may worsen kidney function. - Lithium: increased serum lithium levels. - Methotrexate: reduced renal clearance leading to toxicity.