Paralen 500 Sup (Paracetamol)

Paracetamol, the active ingredient in Paralen 500 Sup, is an analgesic presented as a 500 mg tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children. GNH USA supplies Paralen 500 Sup as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH USA supplies Paralen 500 Sup as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Paracetamol acts on the central pain‑relief and temperature‑regulation pathways. It is commonly used for: - Headache: provides relief from mild to moderate tension‑type headaches. - Fever: reduces elevated body temperature associated with infections or inflammatory conditions. - Musculoskeletal pain: alleviates discomfort from strains, sprains and minor joint aches. - Dental pain: eases postoperative or tooth‑ache discomfort. - Cold symptoms: helps control fever and headache that accompany common colds.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild stomach upset that may occur after ingestion. - Rash: occasional skin redness or mild itching. - Elevated liver enzymes: transient increase detected in laboratory tests.

Serious or Rare Side Effects: - Hepatotoxicity: risk of liver injury with overdose or chronic high‑dose use. - Stevens‑Johnson syndrome: rare severe skin reaction. - Anaphylaxis: extremely rare allergic response requiring immediate medical attention. - Blood disorders: rare cases of thrombocytopenia or neutropenia.

When using Paracetamol, consider the following safety measures: - Dose limits: adhere to maximum daily intake to avoid liver toxicity. - Alcohol use: limit consumption as combined use increases hepatic risk. - Liver disease: use with caution in patients with existing hepatic impairment. - Pregnancy: consult healthcare provider; generally considered low risk when used at recommended doses. - Pediatric use: ensure age‑appropriate dosing and formulation. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Paracetamol may interact with several medicines, requiring attention to dosage and monitoring.

Major Interactions (Avoid): - Warfarin: increased anticoagulant effect may raise bleeding risk.

Moderate Interactions (Monitor Closely): - Isoniazid: combined use can enhance liver toxicity. - Antiepileptics (e.g., carbamazepine, phenytoin): may reduce paracetamol plasma levels. - Rifampicin: may increase metabolism, lowering efficacy. - Alcohol: synergistic hepatotoxic potential. - Certain HIV protease inhibitors: may alter drug clearance.