GNH USA

Europe — EMA

Paracetamol Marel

GNH USA supplies Paracetamol Marel (Paracetamol), a analgesic/antipyretic for pain and fever relief. Request a quote for global supply worldwide today.

Paracetamol

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What is Paracetamol?

Paracetamol, the active ingredient in Paracetamol Marel, is an analgesic presented as a rectal formulation for rectal use. It belongs to the analgesic/antipyretic class and is available over‑the‑counter in the European market for relieving mild to moderate pain and reducing fever in adults and children.

GNH USA supplies Paracetamol Marel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol used for?

Paracetamol Marel acts on the pain and fever pathways to provide symptomatic relief.

- Pain: alleviates mild to moderate bodily pain. - Fever: reduces elevated body temperature. - Headache: eases headache symptoms.

What are the side effects of Paracetamol?

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild stomach upset. - Abdominal discomfort: occasional cramping. - Rash: skin irritation or mild itching. - Dizziness: transient light‑headedness.

Serious or Rare Side Effects: - Severe skin reactions: such as Stevens‑Johnson syndrome. - Hepatotoxicity: liver injury, especially with overdose. - Blood disorders: rare cases of agranulocytosis or thrombocytopenia. - Anaphylaxis: rare severe allergic response.

What precautions apply to Paracetamol?

Paracetamol should be used with attention to specific safety considerations.

- Assess liver function: avoid in severe hepatic impairment. - Avoid alcohol: concurrent use increases risk of liver injury. - Do not exceed recommended dose: higher doses raise toxicity risk. - Use with caution in children: follow pediatric dosing guidelines. - Store at ambient temperature: keep in the original pack, protect from moisture.

What does Paracetamol interact with?

Paracetamol may interact with other medicines, requiring awareness of the interaction level.

Major Interactions (Avoid): - Concurrent use with strong CYP450 inducers (e.g., rifampicin): may reduce efficacy. - Combination with other hepatotoxic drugs (e.g., isoniazid): increased liver risk.

Moderate Interactions (Monitor Closely): - Alcohol consumption: may amplify liver toxicity. - Warfarin: may enhance anticoagulant effect. - Phenobarbital: may lower plasma levels of paracetamol.

Frequently asked questions

What is Paracetamol Marel used for?+
Paracetamol Marel is an over‑the‑counter analgesic and antipyretic supplied in a rectal formulation. It is used to relieve mild to moderate pain such as headaches, musculoskeletal discomfort, and to lower fever in both adults and children when oral administration is not suitable.
How does paracetamol work to relieve pain and fever?+
Paracetamol works by reversibly inhibiting cyclooxygenase enzymes in the central nervous system, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish the perception of pain and reset the hypothalamic temperature set‑point, resulting in fever reduction.
What determines the usual dose of Paracetamol Marel?+
The appropriate dose of Paracetamol Marel is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and any existing medical issues. The prescriber will select the correct amount and frequency according to established guidelines.
Is Paracetamol Marel safe to use during pregnancy or breastfeeding?+
Safety data for rectal paracetamol in pregnancy and lactation are limited, and the pregnancy category is not definitively established. Healthcare providers usually weigh potential benefits against risks before recommending use in pregnant or breastfeeding individuals.
How do I order Paracetamol Marel from GNH USA?+
To place an order, submit an enquiry on the Paracetamol Marel product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Paracetamol Marel compare with ibuprofen?+
Paracetamol Marel and ibuprofen both relieve pain and fever, but they act via different mechanisms. Paracetamol primarily inhibits central COX enzymes with minimal anti‑inflammatory effect, while ibuprofen is a non‑steroidal anti‑inflammatory drug (NSAID) that also reduces inflammation. Choice depends on the clinical situation, patient tolerance, and safety profile.
How should Paracetamol Marel be stored and handled?+
Paracetamol Marel should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.
How is Paracetamol Marel administered rectally?+
Paracetamol Marel is supplied as a rectal suppository. The patient or caregiver should insert the suppository gently into the rectum, preferably after bowel movements, and allow it to dissolve completely. Hand hygiene before and after insertion is recommended.
What are the most serious risks to watch for with Paracetamol Marel?+
The most serious risks include severe liver injury, especially with overdose or chronic high‑dose use, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Immediate medical attention is required if signs of liver dysfunction or severe skin rash develop.
Who should not use Paracetamol Marel?+
Paracetamol Marel should be avoided by individuals with known hypersensitivity to paracetamol, those with severe hepatic impairment, and patients who are concurrently taking other hepatotoxic medications without medical supervision. Children under the recommended age for rectal use should also not receive this product.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol
Route
Rectal Use
Manufacturer
Marel B.V.
Origin
EU

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