GNH USA

Europe — EMA

Paracetamol/Kodein Evolan (Paracetamol, Codeine Phosphate Hemihydrate)

GNH USA supplies Paracetamol/Kodein Evolan (Paracetamol, Codeine phosphate), a analgesic combination for moderate to severe pain and fever.

Paracetamol, Codeine Phosphate Hemihydrate

International sale not permitted. Listed for the domestic market and B2B only.

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What is Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol, the active ingredient in Paracetamol/Kodein Evolan, is an analgesic presented as a combination tablet for oral use. It works together with codeine phosphate hemihydrate to relieve moderate to severe pain and reduce fever in adult patients, and is intended for short‑term management when non‑opioid therapy is insufficient.

GNH USA supplies Paracetamol/Kodein Evolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide.

What is Paracetamol, Codeine Phosphate Hemihydrate used for?

Paracetamol/codeine phosphate is an analgesic combination used for pain management. - Mild to moderate acute pain: provides relief when non‑opioid analgesics alone are inadequate. - Post‑operative pain: helps control discomfort after surgical procedures. - Dental pain: reduces discomfort associated with dental extractions or procedures. - Short‑term severe musculoskeletal pain: used for brief relief of intense flare‑ups.

What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?

Common Side Effects: - Nausea: mild to moderate upset stomach. - Constipation: reduced bowel movements. - Dizziness: feeling light‑headed or unsteady. - Drowsiness: increased sleepiness.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, especially at higher doses. - Severe allergic reaction: rash, swelling, or anaphylaxis. - Liver toxicity: elevated enzymes or hepatic injury, particularly with overdose.

What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol/Kodein Evolan should be used only after assessing pain severity and patient history. - Hepatic impairment: avoid or use with caution in severe liver disease. - Elderly patients: monitor for increased sedation and falls. - Concomitant CNS depressants: do not combine with other opioids, benzodiazepines, or alcohol. - Dependence risk: watch for signs of misuse or addiction. - Store at room temperature: keep in the original pack, protect from moisture.

What does Paracetamol, Codeine Phosphate Hemihydrate interact with?

Paracetamol/Kodein Evolan may interact with several medicines. Major Interactions (Avoid): - Other opioid analgesics: additive risk of respiratory depression. - Benzodiazepines: increased sedation and respiratory compromise. - Alcohol: enhances central nervous system depression. Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., fluoxetine): may raise codeine levels. - CYP3A4 inducers (e.g., rifampicin): may reduce codeine effectiveness. - Anticoagulants (e.g., warfarin): paracetamol can potentiate anticoagulant effect.

Frequently asked questions

What is Paracetamol/Kodein Evolan used for?+
Paracetamol/Kodein Evolan is an oral analgesic combination indicated for the short‑term relief of moderate to severe pain, such as post‑operative discomfort, dental pain, and acute musculoskeletal pain, as well as for reducing fever when non‑opioid options are insufficient.
How does paracetamol work in this product?+
Paracetamol acts centrally by inhibiting cyclooxygenase enzymes, which lowers prostaglandin production in the brain, thereby reducing pain perception and fever. Codeine phosphate is metabolised to morphine, which binds to μ‑opioid receptors in the central nervous system, providing additional analgesic effect.
What is the usual dose of Paracetamol/Kodein Evolan?+
The specific dose and dosing interval are determined by the prescribing clinician based on the patient’s age, weight, pain severity, and overall health status. No universal dosing regimen is provided here; the prescriber will tailor therapy to each individual case.
Is Paracetamol/Kodein Evolan safe during pregnancy or breastfeeding?+
Paracetamol is generally considered low risk in pregnancy when used at recommended doses, but codeine crosses the placenta and may cause neonatal respiratory depression. Breastfeeding mothers should consult a healthcare professional, as codeine can be secreted in breast milk and affect the infant.
How do I order Paracetamol/Kodein Evolan from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature requirements), and necessary import documentation.
How does Paracetamol/Kodein Evolan compare with other pain‑relief options?+
Compared with non‑opioid NSAIDs such as ibuprofen, this combination adds an opioid component, offering stronger analgesia for pain that does not respond to NSAIDs alone. However, it carries additional risks of sedation, respiratory depression, and dependence, which are not typical of NSAIDs.
What are the storage and handling requirements for this product?+
Paracetamol/Kodein Evolan should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the tablets out of reach of children and do not use after the expiry date printed on the label.
How is Paracetamol/Kodein Evolan administered?+
The medication is supplied as oral tablets and should be taken with a full glass of water. It is usually taken with or without food, as directed by the prescriber, and the dosing schedule should be strictly followed to avoid accidental overdose.
What are the most serious risks associated with Paracetamol/Kodein Evolan?+
The most serious risks include respiratory depression, especially when combined with other CNS depressants; severe allergic reactions such as anaphylaxis; and potential liver toxicity if paracetamol is taken in excess or in patients with pre‑existing liver disease.
Who should not use Paracetamol/Kodein Evolan?+
Patients with severe hepatic impairment, uncontrolled respiratory conditions, known hypersensitivity to paracetamol or codeine, or those taking monoamine oxidase inhibitors should avoid this product. It is also contraindicated in children under the age limits set by local regulations for codeine‑containing medicines.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Evolan Pharma Ab
Origin
EU

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