GNH USA

Europe — EMA

Paracetamol/Ibuprofen Zentiva (Ibuprofen, Paracetamol)

GNH USA supplies Paracetamol/Ibuprofen Zentiva (Ibuprofen/Paracetamol), a NSAID and analgesic for pain and fever. Request a quote for global supply.

Ibuprofen, Paracetamol

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What is Ibuprofen, Paracetamol?

Ibuprofen, the active ingredient in Paracetamol/Ibuprofen Zentiva, is a non‑steroidal anti‑inflammatory drug (NSAID) and analgesic presented as a combined oral tablet for systemic use. It treats mild to moderate pain and reduces fever in adults and children when used according to medical guidance.

GNH USA supplies Paracetamol/Ibuprofen Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ibuprofen, Paracetamol used for?

Paracetamol/Ibuprofen Zentiva combines two analgesic pathways to relieve pain and fever. It is indicated for: - Headache: alleviates tension‑type and migraine‑associated pain. - Musculoskeletal pain: reduces discomfort from strains, sprains and low‑back pain. - Fever: lowers elevated body temperature in acute febrile illnesses. - Dental pain: eases postoperative and inflammatory dental discomfort. - Menstrual cramps: mitigates dysmenorrhoeic pain. - Osteoarthritis: provides symptomatic relief of joint pain and stiffness.

What are the side effects of Ibuprofen, Paracetamol?

Paracetamol/Ibuprofen Zentiva may cause a range of adverse reactions. Monitoring is advised, especially in patients with pre‑existing conditions.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Dyspepsia: discomfort or burning in the upper abdomen. - Headache: occasional transient headache. - Dizziness: light‑headed sensation. - Rash: mild skin redness or itching. - Elevated liver enzymes: transient laboratory changes.

Serious or Rare Side Effects: - Gastrointestinal bleeding: severe stomach or intestinal hemorrhage. - Hepatotoxicity: significant liver injury, especially with overdose. - Renal impairment: reduced kidney function or acute kidney injury. - Anaphylaxis: severe allergic reaction with airway compromise. - Stevens‑Johnson syndrome: rare severe skin reaction. - Cardiovascular events: increased risk of heart attack or stroke in susceptible individuals.

What precautions apply to Ibuprofen, Paracetamol?

Before using Paracetamol/Ibuprofen Zentiva, consider the following safety measures: - Assess liver function: avoid use in patients with severe hepatic impairment. - Evaluate kidney health: contraindicated in advanced renal disease. - Review gastrointestinal history: caution in patients with ulcers or bleeding disorders. - Check cardiovascular risk: use cautiously in those with hypertension or heart disease. - Avoid concurrent NSAIDs: do not combine with other non‑steroidal anti‑inflammatory drugs. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

What does Ibuprofen, Paracetamol interact with?

Paracetamol/Ibuprofen Zentiva can interact with several medicines. Review patient medication lists carefully.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding potential. - Lithium: ibuprofen may raise serum lithium levels. - Methotrexate: ibuprofen can reduce renal clearance, raising toxicity. - High‑dose corticosteroids: additive ulcerogenic effect.

Moderate Interactions (Monitor Closely): - ACE inhibitors/ARBs: may diminish antihypertensive effect. - Diuretics: potential for reduced renal perfusion. - Antihypertensives: ibuprofen may blunt blood‑pressure control. - Oral hypoglycemics: possible alteration of glucose control. - Allopurinol: increased risk of skin reactions.

Frequently asked questions

What is Paracetamol/Ibuprofen Zentiva used for?+
Paracetamol/Ibuprofen Zentiva is a fixed‑dose combination of ibuprofen and paracetamol indicated for the relief of mild to moderate pain such as headache, dental pain, musculoskeletal discomfort, menstrual cramps and for the reduction of fever in acute febrile conditions.
How does ibuprofen work in this product?+
Ibuprofen blocks cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2 enzymes, which reduces the production of prostaggletons that trigger inflammation, pain and fever. This anti‑inflammatory action complements the central analgesic effect of paracetamol.
What is the usual dose of Paracetamol/Ibuprofen Zentiv a?+
The dosage regimen is determined by the prescribing clinician based on the patient’s age, weight, clinical condition and any concomitant therapies. The prescriber will specify the appropriate strength and frequency.
Is Paracetamol/Ibuprofen Zentiva safe during pregnancy or breastfeeding?+
Use during pregnancy and lactation should only occur under medical supervision. Ibuprofen is generally avoided in the third trimester, while paracetamol is considered relatively safe when used at recommended doses. A healthcare professional will assess the risk‑benefit balance.
How do I order Paracetamol/Ibuprofen Zentiva from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, providing the required quantity and your institutional credentials. GNH USA works with hospitals, pharmacies and procurement teams worldwide, then replies with pricing, availability, shipping details and any necessary import documentation.
How does this combination compare with using ibuprofen or paracetamol alone?+
The fixed‑dose combination offers synergistic pain relief and fever control, often achieving effective symptom management at lower individual doses than when each agent is used separately. This can reduce the risk of dose‑related side effects while providing broader analgesic coverage.
What are the storage and handling requirements for Paracetamol/Ibuprofen Zentiva?+
Store the tablets at ambient temperature, below 25 °C, in the original packaging to protect from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date.
How is Paracetamol/Ibuprofen Zentiva administered?+
The product is supplied as oral tablets intended for systemic absorption. Patients should swallow the tablet whole with a full glass of water, unless otherwise directed by a healthcare professional.
What are the most serious risks associated with this medication?+
Serious adverse events include gastrointestinal bleeding, severe liver injury, acute kidney injury, anaphylaxis and rare skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if any of these symptoms occur.
Who should not use Paracetamol/Ibuprofen Zentiva?+
Individuals with known hypersensitivity to ibuprofen, paracetamol or any excipients, those with active gastrointestinal ulcers, severe liver or kidney disease, uncontrolled hypertension, or who are in the third trimester of pregnancy should avoid this medication unless a physician advises otherwise.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Ibuprofen, Paracetamol
Route
Oral Use
Manufacturer
Zentiva, K.S.
Origin
EU

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