GNH USA

Europe — EMA

Paracetamol/Ibuprofen Zentiva (Ibuprofen, Paracetamol)

GNH USA supplies Paracetamol/Ibuprofen Zentiva (Ibuprofen/Paracetamol), a NSAID and analgesic for pain and fever. Request a quote for global supply.

Ibuprofen, Paracetamol

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What is Ibuprofen, Paracetamol?

Ibuprofen, the active ingredient in Paracetamol/Ibuprofen Zentiva, is a non‑steroidal anti‑inflammatory drug (NSAID) and analgesic presented as a combination tablet for oral use. It treats pain and fever in adults and children when both ibuprofen and paracetamol are indicated.

GNH USA supplies Paracetamol/Ibuprofen Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ibuprofen, Paracetamol used for?

Paracetamol/Ibuprofen Zentiva combines two analgesic pathways to provide relief in several common conditions.

- Headache: reduces pain intensity and associated discomfort. - Dental pain: alleviates postoperative and inflammatory dental discomfort. - Musculoskeletal pain: eases aches, strains and sprains. - Fever: lowers elevated body temperature in febrile states. - Minor arthritic pain: provides short‑term relief of mild osteoarthritis symptoms.

What are the side effects of Ibuprofen, Paracetamol?

Paracetamol/Ibuprofen Zentiva may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild stomach upset that often resolves without treatment. - Dyspepsia: discomfort or burning sensation in the upper abdomen. - Headache: transient headache unrelated to the condition being treated. - Dizziness: occasional light‑headed feeling. - Rash: mild skin redness or itching.

Serious or Rare Side Effects: - Gastrointestinal bleeding: black or tarry stools, vomiting blood. - Liver injury: jaundice, dark urine, elevated liver enzymes. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Anaphylaxis: rapid onset of swelling, difficulty breathing, or shock. - Renal impairment: reduced urine output, swelling of limbs.

What precautions apply to Ibuprofen, Paracetamol?

When using Paracetamol/Ibuprofen Zentiva, consider the following safety measures.

- Assess renal function: patients with kidney disease should be monitored. - Evaluate hepatic health: avoid in severe liver impairment. - Limit alcohol intake: concurrent use may increase liver toxicity risk. - Avoid in third‑trimester pregnancy: potential fetal harm. - Use lowest effective dose: minimize risk of gastrointestinal irritation. - Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

What does Ibuprofen, Paracetamol interact with?

Paracetamol/Ibuprofen Zentiva can interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding potential.

Moderate Interactions (Monitor Closely): - ACE inhibitors: possible reduction in renal function. - Diuretics: may enhance nephrotoxic effects. - Lithium: ibuprofen can raise serum lithium levels. - Methotrexate: ibuprofen may reduce clearance, increasing toxicity.

Frequently asked questions

What is Paracetamol/Ibuprofen Zentiva used for?+
Paracetamol/Ibuprofen Zentiva is a fixed‑dose combination of ibuprofen and paracetamol intended to relieve mild to moderate pain and reduce fever. It is commonly used for headaches, dental pain, musculoskeletal aches, and short‑term management of febrile episodes in adults and children when both agents are appropriate.
How does ibuprofen work in this product?+
Ibuprofen blocks cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2 enzymes, which reduces the production of prostaglandins that cause inflammation, pain and fever. By lowering prostaglandin levels, ibuprofen diminishes the inflammatory response and provides analgesic and antipyretic effects.
What is the usual dose of Paracetamol/Ibuprofen Zentiva?+
The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, clinical condition and any concurrent therapies. Healthcare professionals set the dosage regimen to ensure safety and effectiveness, following local prescribing guidelines.
Is Paracetamol/Ibuprofen Zentiva safe during pregnancy or breastfeeding?+
Use of this combination is generally avoided in the third trimester of pregnancy because ibuprofen may affect fetal cardiovascular development. Caution is advised throughout pregnancy and while breastfeeding; clinicians should evaluate the risk‑benefit profile for each individual.
How do I order Paracetamol/Ibuprofen Zentiva from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does this combination compare with using ibuprofen or paracetamol alone?+
Combining ibuprofen with paracetamol can provide additive analgesic and antipyretic effects, often achieving better pain control than either agent alone while allowing lower individual doses. This may reduce the risk of dose‑related side effects compared with high‑dose monotherapy, though combination therapy still requires careful monitoring.
What are the storage and handling requirements for Paracetamol/Ibuprofen Zentiva?+
Store the tablets at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme heat or humidity.
How is Paracetamol/Ibuprofen Zentiva administered?+
The product is supplied as oral tablets that should be swallowed whole with water. It is intended for systemic absorption via the gastrointestinal tract; it should not be crushed, chewed, or dissolved unless specifically directed by a healthcare professional.
What are the most serious risks associated with this medication?+
Serious risks include gastrointestinal bleeding, severe liver injury, acute kidney injury, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs like black stools, jaundice, swelling, or a widespread rash.
Who should not take        ​       ??+
Individuals with known hypersensitivity to ibuprofen, par‑par 
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Ibuprofen, Paracetamol
Route
Oral Use
Manufacturer
Zentiva, K.S.
Origin
EU

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