GNH USA

Europe — EMA

Paracetamol/Ibuprofen Jed (Ibuprofen, Paracetamol)

GNH USA supplies Paracetamol/Ibuprofen Jed (Ibuprofen/Paracetamol), a analgesic/antipyretic for pain, fever and inflammation.

Ibuprofen, Paracetamol

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What is Ibuprofen, Paracetamol?

Ibuprofen, the active ingredient in Paracetamol/Ibuprofen Jed, is an analgesic and non‑steroidal anti‑inflammatory drug presented as a combined formulation for oral use. It treats pain, fever and inflammation in adults and children when prescribed by a healthcare professional.

GNH USA supplies Paracetamol/Ibuprofen Jed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ibuprofen, Paracetamol used for?

Paracetamol/Ibuprofen Jed combines two well‑known analgesic agents that act on the prostaglandin pathway to relieve discomfort and reduce fever. - Headache: provides rapid relief of mild to moderate headache pain. - Musculoskeletal pain: eases muscle, joint and back pain associated with strain or arthritis. - Fever: lowers elevated body temperature in acute febrile illnesses.

What are the side effects of Ibuprofen, Paracetamol?

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Nausea: mild stomach upset that often resolves without intervention. - Dyspepsia: discomfort or burning sensation in the upper abdomen. - Headache: occasional worsening of headache despite treatment. - Dizziness: transient light‑headedness, especially on standing. - Rash: mild skin redness or itching. - Elevated liver enzymes: mild, reversible changes in blood tests.

Serious or Rare Side Effects: - Gastrointestinal bleeding: black or tarry stools, vomiting blood, or severe abdominal pain. - Hepatotoxicity: significant liver injury presenting with jaundice, dark urine, or fatigue. - Renal impairment: reduced urine output, swelling, or sudden weight gain. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Anaphylaxis: rapid onset of breathing difficulty, swelling of the face or throat, and hypotension. - Thrombotic events: increased risk of heart attack or stroke, especially with high‑dose ibuprofen.

What precautions apply to Ibuprofen, Paracetamol?

When using Paracetamol/Ibuprofen Jed, consider the following safety measures: - Assess liver function: review patients with existing liver disease. - Evaluate renal function: caution in individuals with chronic kidney disease. - Monitor cardiovascular risk: avoid high‑dose or prolonged ibuprofen use in at‑risk patients. - Avoid concurrent NSAIDs: do not combine with other non‑steroidal anti‑inflammatory drugs. - Limit alcohol intake: excessive alcohol can increase hepatotoxic risk. - Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

What does Ibuprofen, Paracetamol interact with?

Paracetamol/Ibuprofen Jed can interact with several medicines; clinicians should review patient medication lists.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency. - Lithium: ibuprofen may raise lithium serum levels, risking toxicity. - Methotrexate: ibuprofen can reduce renal clearance, raising methotrexate toxicity. - ACE inhibitors/ARBs: may diminish renal protective effects and increase kidney injury risk.

Moderate Interactions (Monitor Closely): - Diuretics: potential for reduced diuretic efficacy and electrolyte imbalance. - Corticosteroids: additive risk of gastrointestinal ulceration. - Antihypertensives: ibuprofen may blunt blood‑pressure‑lowering effects. - Anticonvulsants (e.g., carbamazepine): may alter paracetamol metabolism. - Oral hypoglycemics: ibuprofen can affect glucose control in some patients.

Frequently asked questions

What is Paracetamol/Ibuprofen Jed used for?+
Paracetamol/Ibuprofen Jed is a fixed‑dose combination of paracetamol and ibuprofen that provides analgesic, antipyretic and anti‑inflammatory effects. It is commonly prescribed to relieve mild‑to‑moderate pain such as headache, musculoskeletal discomfort, and to lower fever in adults and children when a single agent may be insufficient.
How does ibuprofen work in this combination?+
Ibuprofen inhibits peripheral cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins that mediate inflammation, pain and fever. By lowering prostaglandin levels at the site of injury, ibuprofen adds anti‑inflammatory and analgesic activity to the central effects of paracetamol.
What is the usual dose of Paracetamol/Ibuprofen Jed?+
The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, clinical condition and any concomitant therapies. Healthcare providers follow local prescribing guidelines and product labeling to select the correct strength and dosing interval.
Is Paracetamol/Ibuprofen Jed safe during pregnancy or breastfeeding?+
Paracetamol is generally considered safe in pregnancy when used at recommended doses, while ibuprofen is usually avoided, especially in the third trimester, due to potential fetal risks. Breastfeeding mothers should consult their healthcare professional, as ibuprofen passes into milk in small amounts and may affect the infant.
How do I order Paracetamol/Ibuprofen Jed from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does this combination compare with using paracetamol or ibuprofen alone?+
The fixed‑dose combination offers synergistic pain and fever control by targeting both central and peripheral prostaglandin pathways, often achieving faster and more complete relief than either agent alone. However, the combined safety profile requires careful assessment of liver and kidney function, and it may not be suitable for patients with contraindications to either component.
What are the storage requirements for Paracetamol/Ibuprofen Jed?+
Store the product at ambient temperature, preferably below 25 °C, in the original container to protect it from moisture and direct sunlight. Ensure the packaging remains sealed until use to maintain product stability.
How is Paracetamol/Ibuprofen Jed administered?+
Paracetamol/Ibuprofen Jed is intended for oral administration. Tablets or capsules should be swallowed whole with a full glass of water, unless the product label specifies an alternative method such as dispersing in water for patients with swallowing difficulties.
What are the most serious risks associated with this medication?+
Serious risks include gastrointestinal bleeding, severe liver injury, acute kidney failure, allergic reactions such as anaphylaxis, and rare but life‑threatening skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of these adverse events.
Who should not use Paracetamol/Ibuprofen Jed?+
Individuals with known hypersensitivity to paracetamol, ibuprofen or other NSAIDs, active peptic ulcer disease, severe liver or kidney impairment, uncontrolled hypertension, or those in the third trimester of pregnancy should avoid this combination. Clinicians must evaluate each patient’s medical history before prescribing.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Ibuprofen, Paracetamol
Route
Intravenous Use
Manufacturer
Jed Pharma Ltd
Origin
EU

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