Paracetamol + Difenhydramina Noc Hasco (Diphenhydramine Hydrochloride, Paracetamol)

Paracetamol, the active ingredient in Paracetamol + Difenhydramina Noc Hasco, is an analgesic/antipyretic presented as an oral tablet for oral use. It relieves mild to moderate pain, reduces fever, and, in combination with diphenhydramine, helps control allergy‑related symptoms in adults and children. GNH USA supplies Paracetamol + Difenhydramina Noc Hasco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Paracetamol combined with diphenhydramine acts on pain, fever and histamine‑mediated allergic pathways. - Mild to moderate pain: provides analgesic relief for headaches, musculoskeletal discomfort and dental pain. - Fever: lowers elevated body temperature associated with infections or inflammatory conditions. - Allergic rhinitis or common cold symptoms: alleviates nasal congestion, sneezing, itching and watery eyes caused by histamine release.

Paracetamol + diphenhydramine may cause a range of adverse reactions.

Common Side Effects: - Drowsiness or sedation - Dry mouth or throat - Nausea or upset stomach - Dizziness or light‑headedness - Blurred vision - Constipation or mild urinary retention

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) with rash, swelling, or difficulty breathing - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Hepatotoxicity, especially with overdose of paracetamol - Cardiac arrhythmias or tachycardia - Seizures in overdose situations - Severe skin reactions such as drug reaction with eosinophilia and systemic symptoms (DRESS)

When using Paracetamol + diphenhydramine, consider the following precautions. - Assess liver function: avoid in patients with severe hepatic impairment. - Avoid alcohol: concurrent intake increases risk of liver injury. - Use caution in the elderly: heightened susceptibility to sedation and anticholinergic effects. - Do not exceed the recommended daily dose of paracetamol to prevent hepatotoxicity. - Avoid concomitant CNS depressants: may enhance drowsiness and impair coordination. - Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Paracetamol + diphenhydramine can interact with several medicines.

Major Interactions (Avoid): - Other paracetamol‑containing products: risk of cumulative overdose and liver damage. - Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase diphenhydramine plasma levels. - Alcoholic beverages: potentiate hepatotoxic risk of paracetamol.

Moderate Interactions (Monitor Closely): - Anticoagulants such as warfarin: may enhance bleeding tendency. - Other CNS depressants (benzodiazepines, opioids, antihistamines): increased sedation and respiratory depression. - Anticholinergic drugs (e.g., atropine, tricyclic antidepressants): additive dry‑mouth and urinary retention effects.