GNH USA

Europe — EMA

Paracetamol Comp. (Paracetamol, Codeine Phosphate Hemihydrate)

GNH USA supplies Paracetamol Comp. (Paracetamol, Codeine), a combination analgesic for moderate pain, fever and dental discomfort. Request a quote for supply.

Paracetamol, Codeine Phosphate Hemihydrate

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What is Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol and Codeine Phosphate Hemihydrate, the active ingredients in Paracetamol Comp., are analgesic agents presented as an oral combination tablet for adult use. They provide relief of mild to moderate pain, reduce fever, and are commonly employed for dental discomfort and headache management in patients requiring opioid‑enhanced analgesia. The combination acts quickly to improve comfort.

GNH USA supplies Paracetamol Comp. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures timely delivery and regulatory compliance across regions.

What is Paracetamol, Codeine Phosphate Hemihydrate used for?

Paracetamol/Codeine combination analgesic is used for pain and fever management across several clinical conditions.

Mild to moderate pain: provides effective analgesia for musculoskeletal and postoperative discomfort. Fever: reduces elevated body temperature. Dental pain: alleviates postoperative dental discomfort. Headache: relieves tension‑type headache.

What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol Comp. may cause a range of adverse reactions.

Common Side Effects: - Nausea - Constipation - Drowsiness - Dizziness - Dry mouth - Mild itching

Serious or Rare Side Effects: - Respiratory depression - Severe allergic reactions (anaphylaxis) - Hepatotoxicity - Dependence or abuse potential - Severe hypotension - Seizures

What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?

Use of Paracetamol Comp. requires careful consideration of patient‑specific factors. - Pregnancy: use only if clearly needed after risk assessment. - Liver disease: avoid or adjust dose due to hepatotoxic risk. - Alcohol consumption: limit intake as it may increase sedation and liver strain. - Driving and operating machinery: may cause drowsiness; caution advised. - Children and adolescents: not recommended unless specifically prescribed. - Store at ambient temperature: keep in the original container, protect from moisture.

What does Paracetamol, Codeine Phosphate Hemihydrate interact with?

Paracetamol Comp. can interact with other medicines, influencing safety and efficacy.

Major Interactions (Avoid): - Central nervous system depressants (e.g., benzodiazepines, barbiturates) - Monoamine oxidase (MAO) inhibitors - Alcohol - Other opioid analgesics - CYP2D6 inhibitors (e.g., fluoxetine) that may raise codeine levels

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampicin) may reduce analgesic effect - Antihistamines may increase sedation

Frequently asked questions

What is Paracetamol Comp. used for?+
Paracetamol Comp. is a fixed‑dose combination of paracetamol and codeine phosphate hemihydrate. It is prescribed to relieve mild to moderate pain, reduce fever, and manage dental discomfort or tension‑type headaches when an opioid‑enhanced analgesic is appropriate.
How does the active ingredient work?+
Paracetamol reduces pain and fever by inhibiting central cyclooxygenase enzymes, lowering prostaglandin production. Codeine phosphate hemihydrate is a pro‑drug converted to morphine, which activates μ‑opioid receptors in the brain and spinal cord, producing analgesia and cough suppression.
What is the usual dose?+
The dose of Paracetamol Comp. is determined by the prescribing clinician based on the patient’s age, weight, pain severity, and clinical condition. Patients should follow the prescriber’s instructions and never adjust the dose without medical advice.
Is it safe in pregnancy or breastfeeding?+
Safety in pregnancy and lactation has not been fully established. The product should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under the guidance of a qualified health professional.
How do I order Paracetamol Comp. from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does it compare with other analgesics?+
Compared with paracetamol alone, the addition of codeine provides stronger analgesia and can address moderate pain that may not respond to non‑opioid therapy. Compared with stronger opioids, the combination offers a lower risk of severe respiratory depression but still requires careful monitoring.
How should it be stored and handled?+
Store Paracetamol Comp. at ambient temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep out of reach of children and do not use after the expiry date printed on the label.
How is Paracetamol Comp. administered?+
The product is taken orally, usually with a glass of water. It may be taken with or without food, but if gastrointestinal upset occurs, it can be taken with a light meal. Swallow tablets whole; do not crush or chew unless instructed by a healthcare professional.
What are the most serious risks to watch for?+
Serious risks include respiratory depression, especially when combined with other CNS depressants, severe allergic reactions, hepatotoxicity from excessive paracetamol exposure, and the potential for dependence or abuse associated with codeine. Immediate medical attention is required if any of these occur.
Who should not use Paracetamol Comp.?+
The product should be avoided in individuals with known hypersensitivity to paracetamol or codeine, severe respiratory depression, uncontrolled liver disease, or those taking MAO inhibitors. It is also contraindicated in children under the age specified by local regulations unless prescribed by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Stadapharm Gmbh
Origin
EU

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