N – Calmant Iii

Paracetamol, Codeine Phosphate Hemihydrate and Caffeine, the active ingredients in N – Calmant III, are analgesic, antipyretic and central nervous system stimulant agents presented as an oral tablet for oral use. The combination provides relief of mild to moderate pain such as headache, musculoskeletal or dental pain, and reduces fever in adult patients.

GNH USA supplies N – Calmant III as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide through diverse markets and healthcare providers globally.

N – Calmant III targets pain and fever pathways to provide symptomatic relief.

Headache: reduces pain intensity and improves daily functioning in adult patients. Musculoskeletal pain: alleviates aches and stiffness associated with strains or arthritis. Dental pain: eases postoperative or procedural discomfort after dental work. Fever: lowers elevated body temperature in febrile conditions.

Common Side Effects: - Nausea or upset stomach. - Dizziness or light‑headedness. - Drowsiness or mild sedation. - Constipation. - Dry mouth. - Increased heart rate.

Serious or Rare Side Effects: - Respiratory depression, especially with high doses or in susceptible individuals. - Severe allergic reactions such as rash, swelling, or anaphylaxis. - Liver toxicity with prolonged or excessive paracetamol intake. - Seizures in rare cases. - Dependence or withdrawal symptoms with prolonged codeine use.

Before using N – Calmant III, consider the following precautions: - Liver function assessment: avoid in patients with severe hepatic impairment. - Respiratory disorders: use cautiously in asthma or COPD. - Age restriction: not recommended for children under 12 years. - CNS depressants: avoid concurrent use with alcohol, benzodiazepines, or other opioids. - Dependence risk: monitor for signs of misuse with prolonged therapy. - Store at room temperature: keep in the original pack, protect from moisture.

N – Calmant III may interact with several medicines. Review the following:

Major Interactions (Avoid): - Other opioid analgesics: risk of additive respiratory depression. - Central nervous system depressants (e.g., benzodiazepines, barbiturates): may enhance sedation and respiratory effects. - Alcohol: increases risk of hepatotoxicity and CNS depression.

Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., fluoxetine, quinidine): can raise codeine plasma levels. - Antihistamines or decongestants: may augment drowsiness or cardiovascular effects.