GNH USA

Europe — EMA

Paracetamol/Codeine Phosphate Hemihydrate Accord (Paracetamol, Codeine Phosphate Hemihydrate)

GNH USA supplies Paracetamol/Codeine Accord (Paracetamol/Codeine), a analgesic for moderate pain and fever. Request a quote for global supply.

Paracetamol, Codeine Phosphate Hemihydrate

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What is Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol, the active ingredient in Paracetamol/Codeine Phosphate Hemihydrate Accord, is an analgesic presented as a combination tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children when appropriate. GNH USA supplies Paracetamol/Codeine Phosphate Hemihydrate Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Paracetamol/Codeine Phosphate Hemihydrate Accord is provided by GNH USA, a licensed, GDP‑compliant supplier to hospitals, pharmacies and clinics worldwide.

What is Paracetamol, Codeine Phosphate Hemihydrate used for?

Paracetamol/Codeine phosphate hemihydrate is an analgesic that acts on the nociceptive pain pathway and is used for short‑term relief of moderate pain. - Dental pain: provides relief of pain following dental procedures or toothache. - Musculoskeletal pain: reduces discomfort from strains, sprains and low‑back pain. - Post‑operative pain: helps control pain after minor surgical interventions. - Headache and migraine: eases moderate headache symptoms when simple analgesics are insufficient. - Fever: lowers elevated body temperature associated with infection or inflammation.

What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol/Codeine phosphate hemihydrate may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Constipation: reduced bowel movements. - Drowsiness: feeling of sleepiness. - Dizziness: light‑headed sensation. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Respiratory depression: slowed or shallow breathing, especially at higher doses. - Hepatotoxicity: liver injury from excessive paracetamol exposure. - Allergic reactions: rash, itching, swelling or anaphylaxis. - Seizures: rare occurrence, often linked to overdose. - Dependence or withdrawal: potential with prolonged codeine use.

What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?

When using Paracetamol/Codeine phosphate hemihydrate, consider the following safety measures: - Liver function monitoring: assess hepatic health before long‑term use. - Alcohol use: avoid excessive alcohol as it increases hepatotoxic risk. - Opioid sensitivity: assess for heightened response to codeine in opioid‑naïve patients. - Pregnancy and lactation: use only if clearly indicated and prescribed. - Concomitant CNS depressants: monitor for additive sedation. - Store at below 25°C: keep in the original packaging, protect from moisture and light.

What does Paracetamol, Codeine Phosphate Hemihydrate interact with?

Paracetamol/Codeine phosphate hemihydrate can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): reduce conversion of codeine to morphine, lowering analgesic effect. - CNS depressants (benzodiazepines, barbiturates): increase risk of respiratory depression. - Alcohol: potentiates hepatotoxicity and sedation.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - Antihistamines: can increase drowsiness. - Diuretics: may affect renal clearance of paracetamol.

Frequently asked questions

What is Paracetamol/Codeine phosphate hemihydrate Accord used for?+
Paracetamol/Codeine phosphate hemihydrate Accord is a combination analgesic used for short‑term relief of moderate pain such as dental, musculoskeletal or post‑operative discomfort, and for reducing fever when simpler agents are insufficient.
How does Paracetamol work in this product?+
Paracetamol reduces pain and fever by inhibiting central cyclo‑oxygenase enzymes, which lowers prostaglandin production in the brain, thereby decreasing pain signalling and resetting the hypothalamic temperature set‑point.
What is the usual dose of Paracetamol/Codeine Accord?+
The prescribed dose is determined by the treating clinician based on the patient’s age, weight, pain severity and medical history; the prescriber sets the exact regimen.
Is Paracetamol/Codeine Accord safe during pregnancy or breastfeeding?+
Use during pregnancy or lactation is only recommended when clearly indicated by a healthcare professional, as codeine crosses the placenta and may affect the newborn, and high‑dose paracetamol can impact liver function.
How do I order Paracetamol/Codeine Accord from GNH USA?+
Submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does this product compare with other analgesics?+
Compared with single‑ingredient paracetamol, the addition of codeine provides stronger analgesia for moderate pain but introduces opioid‑related risks. It is less potent than stronger opioids such as morphine, offering a balance between efficacy and safety for short‑term use.
What are the storage and handling requirements?+
Store the tablets at temperatures below 25 °C in the original container, protected from moisture and light. Do not expose to excessive heat or humidity to maintain product stability.
How is Paracetamol/Codeine Accord administered?+
The medication is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing and any food considerations.
What are the most serious risks associated with this medication?+
Serious risks include respiratory depression, especially when combined with other CNS depressants, hepatotoxicity from excessive paracetamol, allergic reactions such as anaphylaxis, and the potential for dependence or withdrawal with prolonged codeine use.
Who should not use Paracetamol/Codeine Accord?+
Individuals with severe liver disease, known hypersensitivity to paracetamol or codeine, those taking strong CYP2D6 inhibitors, or patients with a history of opioid dependence should avoid this medication unless specifically directed by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Accord Healthcare Ireland Limited
Origin
EU

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