GNH USA

Europe — EMA

Paracetamol / Codeine Phosphate Hemihydrate Accord (Paracetamol, Codeine Phosphate Hemihydrate)

GNH USA supplies Paracetamol / Codeine Phosphate Hemihydrate Accord (Paracetamol / Codeine Phosphate Hemihydrate), an Analgesic for mild to moderate pain

Paracetamol, Codeine Phosphate Hemihydrate

International sale not permitted. Listed for the domestic market and B2B only.

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What is Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol / Codeine Phosphate Hemihydrate, the active ingredient in Paracetamol / Codeine Phosphate Hemihydrate Accord, is an Analgesic presented as a strength/form not specified for oral use. It provides relief of mild to moderate pain and reduces fever in adult patients.

GNH USA supplies Paracetamol / Codeine Phosphate Hemihydrate Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide. The product meets EU quality standards and is available for bulk distribution to meet global demand.

What is Paracetamol, Codeine Phosphate Hemihydrate used for?

Paracetamol / Codeine Phosphate Hemihydrate is used to manage pain and fever through its combined analgesic and antipyretic actions.

- Mild to moderate pain: alleviates discomfort from headaches, dental procedures, musculoskeletal injuries. - Fever: reduces elevated body temperature in febrile conditions. - Post‑operative pain: provides relief after minor surgical interventions.

What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol / Codeine Phosphate Hemihydrate may cause a range of adverse reactions, varying from common to serious.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Constipation: reduced bowel movements. - Dizziness: sensation of light‑headedness. - Drowsiness: increased sleepiness. - Vomiting: occasional emesis. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, especially with high doses. - Severe allergic reaction: rash, itching, swelling, or anaphylaxis. - Hepatic injury: elevated liver enzymes or jaundice. - Dependence or abuse potential: risk of opioid misuse. - Seizures: rare occurrence in susceptible individuals.

What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?

When prescribing Paracetamol / Codeine Phosphate Hemihydrate, clinicians should observe specific safety measures to minimize risk.

- Dose adjustment: use the lowest effective dose as directed by the prescriber. - Hepatic impairment: avoid or reduce use in patients with severe liver disease. - Respiratory conditions: exercise caution in individuals with asthma or chronic obstructive pulmonary disease. - Concomitant CNS depressants: limit use with alcohol, benzodiazepines, or other sedatives. - Dependence monitoring: assess for signs of opioid misuse during therapy. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

What does Paracetamol, Codeine Phosphate Hemihydrate interact with?

Paracetamol / Codeine Phosphate Hemihydrate can interact with other medicines, affecting safety and efficacy.

Major Interactions (Avoid): - Other opioids: additive risk of respiratory depression and profound sedation. - Benzodiazepines or CNS depressants: increased sedation and impaired psychomotor function. - Alcohol: enhances central nervous system depression, raising overdose risk.

Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may reduce conversion of codeine to morphine, lowering analgesic effect. - CYP3A4 inducers (e.g., rifampicin, carbamazepine): may decrease paracetamol plasma levels, reducing efficacy. - Anticoagulants (e.g., warfarin): high‑dose paracetamol may potentiate anticoagulant effect, requiring INR monitoring.

Frequently asked questions

What is Paracetamol / Codeine Phosphate Hemihydrate Accord used for?+
Paracetamol / Codeine Phosphate Hemihydrate Accord is prescribed to relieve mild to moderate pain such as headache, dental or musculoskeletal discomfort, and to lower fever in adult patients. The combination leverages both analgesic and antipyretic properties to provide effective symptom control.
How does Paracetamol / Codeine Phosphate Hemihydrate work?+
Paracetamol reduces pain and fever by centrally inhibiting cyclooxygenase enzymes, which lowers prostaglandin production. Codeine phosphate hemihydrate is metabolised by the liver enzyme CYP2D6 into morphine, which activates μ‑opioid receptors in the brain, altering pain perception and adding a sedative effect. Together they produce synergistic relief.
What is the usual dose of Paracetamol / Codeine Phosphate Hemihydrate?+
The exact dose is determined by the prescribing clinician based on the patient’s age, weight, severity of symptoms, and overall health status. Healthcare professionals tailor the regimen to achieve optimal pain control while minimizing risk, and patients should follow the prescriber’s instructions without deviation.
Is Paracetamol / Codeine Phosphate Hemihydrate safe in pregnancy or breastfeeding?+
Use during pregnancy or lactation should only occur when clearly indicated and after a risk‑benefit assessment by a qualified healthcare provider. Codeine can cross the placenta and be excreted in breast milk, potentially affecting the infant, so alternative therapies are often preferred.
How do I order Paracetamol / Codeine Phosphate Hemihydrate Accord from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Paracetamol / Codeine Phosphate Hemihydrate compare with other pain relievers?+
Compared with non‑opioid NSAIDs such as ibuprofen, this combination offers stronger analgesia for moderate pain due to the opioid component, while still providing antipyretic action. Unlike pure opioid preparations, the lower dose of codeine reduces the risk of severe side effects, but it still carries dependence potential.
How should Paracetamol / Codeine Phosphate Hemihydrate be stored and handled?+
Store the product at ambient temperature, ideally below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. Do not refrigerate or freeze the tablets unless the label specifically advises otherwise.
How is Paracetamol / Codeine Phosphate Hemihydrate administered?+
The medication is taken orally, usually with a full glass of water. It may be taken with or without food, depending on the prescriber’s guidance. Swallow the tablet whole; do not crush, chew, or split it unless instructed, as this could affect absorption and increase side‑effect risk.
What are the most serious risks associated with Paracetamol / Codeine Phosphate Hemihydrate?+
The most critical concerns include respiratory depression, especially in opioid‑naïve patients or when combined with other depressants, severe allergic reactions, hepatic injury from excessive paracetamol exposure, and the potential for dependence or abuse of the codeine component. Prompt medical attention is required if any of these occur.
Who should not use Paracetamol / Codeine Phosphate Hemihydrate?+
Patients with known hypersensitivity to paracetamol, codeine, or any excipients should avoid the product. It is contraindicated in individuals with severe hepatic impairment, uncontrolled respiratory disorders, or a history of opioid dependence. Children under the age specified by local regulations should not receive this formulation without specialist advice.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Accord Healthcare B.V.
Origin
EU

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