GNH USA

Europe — EMA

Paracetamol/Codeïnefosfaat Accord Healthcare (Paracetamol, Codeine Phosphate Hemihydrate)

GNH USA supplies Paracetamol/Codeïnefosfaat Accord Healthcare (Paracetamol/Codeine), a analgesic combination for pain relief and fever reduction.

Paracetamol, Codeine Phosphate Hemihydrate

International sale not permitted. Listed for the domestic market and B2B only.

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What is Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol, the active ingredient in Paracetamol/Codeïnefosfaat Accord Healthcare, is an analgesic combination presented as a tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children when appropriate. GNH USA supplies Paracetamol/Codeïnefosfaat Accord Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Paracetamol/Codeïnefosfaat Accord Healthcare is provided by GNH USA, a licensed, GDP‑compliant supplier to hospitals, pharmacies and clinics worldwide.

What is Paracetamol, Codeine Phosphate Hemihydrate used for?

Paracetamol/Codeine Phosphate Hemihydrate is used for pain relief in several common conditions where moderate analgesia is required. - Dental pain: provides effective relief of postoperative dental discomfort. - Musculoskeletal pain: reduces pain associated with strains, sprains and low‑back pain. - Headache and migraine: alleviates moderate intensity headache episodes. - Post‑operative pain: helps control pain after minor surgical procedures. - Fever: lowers elevated body temperature associated with infection or inflammation.

What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol/Codeine Phosphate Hemihydrate may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Constipation: reduced bowel movements. - Drowsiness: feeling of sleepiness or reduced alertness. - Dizziness: light‑headed sensation. - Dry mouth: reduced salivary flow.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, especially at higher doses. - Hepatotoxicity: liver injury from excessive paracetamol exposure. - Allergic reactions: rash, itching, swelling or anaphylaxis. - Dependence or misuse: potential for opioid‑related dependence with prolonged use. - Seizures: rare occurrence, particularly in overdose situations.

What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?

When prescribing Paracetamol/Codeine Phosphate Hemihydrate, clinicians should consider several safety aspects. - Liver function: avoid use in patients with severe hepatic impairment. - Respiratory conditions: use cautiously in asthma or chronic obstructive pulmonary disease. - Opioid sensitivity: assess risk of dependence in patients with a history of substance abuse. - Pregnancy and lactation: limit use to situations where benefits outweigh risks. - Concomitant CNS depressants: monitor for enhanced sedation. - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

What does Paracetamol, Codeine Phosphate Hemihydrate interact with?

Paracetamol/Codeine Phosphate Hemihydrate can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may reduce codeine conversion to active metabolite. - CNS depressants (e.g., benzodiazepines, alcohol): increase risk of respiratory depression. - MAO inhibitors: heightened risk of serotonin syndrome when combined with codeine.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - Anticholinergic agents: may worsen constipation. - Diuretics: potential for reduced renal clearance of paracetamol.

Frequently asked questions

What is Paracetamol/Codeïnefosfaat Accord Healthcare used for?+
Paracetamol/Codeïnefosfaat Accord Healthcare is an oral analgesic combination used to relieve moderate pain such as dental, musculoskeletal, postoperative or headache pain, and to reduce fever when a stronger effect than paracetamol alone is required.
How does Paracetamol/Codeine work?+
Paracetamol reduces pain by inhibiting central cyclooxygenase enzymes, lowering prostaglandin production. Codeine binds to µ‑opioid receptors in the brain and spinal cord, providing additional analgesia and a mild cough‑suppression effect. Together they give additive pain relief.
What is the usual dose of Paracetamol/Codeine?+
The prescribed dose of Paracetamol/Codeine is individualized by a healthcare professional based on the patient’s age, weight, pain severity and clinical condition. The prescriber determines the appropriate strength, frequency and duration of therapy.
Is Paracetamol/Codeine safe during pregnancy or breastfeeding?+
Paracetamol/Codeine should only be used in pregnancy or while breastfeeding when the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers usually limit use to short‑term treatment and consider alternative analgesics when possible.
How do I order Paracetamol/Codeïnefosfaat Accord Healthcare from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does this product compare with other analgesic options?+
Compared with paracetamol alone, the addition of codeine provides stronger analgesia for moderate pain but introduces opioid‑related risks such as dependence and respiratory depression. It is less potent than stronger opioids like morphine, offering a balance between efficacy and safety for many outpatient settings.
What are the storage requirements for Paracetamol/Codeine tablets?+
Store the tablets below 25 °C in their original container, protecting them from moisture, heat and direct sunlight. Do not use the product after the expiry date printed on the packaging.
How is Paracetamol/Codeine administered?+
The medication is taken orally, usually with a glass of water. It may be taken with or without food, but taking it with food can reduce stomach upset. Patients should follow the dosing instructions provided by their prescriber.
What are the most serious risks associated with Paracetamol/Codeine?+
Serious risks include respiratory depression, especially in opioid‑naïve individuals or when combined with other depressants, and liver injury from excessive paracetamol exposure. Allergic reactions and potential dependence with prolonged use are also important safety concerns.
Who should not use Paracetamol/Codeine?+
Individuals with severe hepatic impairment, known hypersensitivity to paracetamol or codeine, significant respiratory disorders, or a history of opioid dependence should avoid this medication. It is also contraindicated in children under the age limits set by local regulatory authorities.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Accord Healthcare B.V.
Origin
EU

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