Europe — EMA
Paracetamol/Codeína Kern Pharma (Paracetamol, Codeine Phosphate Hemihydrate)
GNH USA supplies Paracetamol/Codeína Kern Pharma (Paracetamol/Codeine), a combination analgesic for pain and fever. Request a quote for global supply.
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What is Paracetamol, Codeine Phosphate Hemihydrate?
Paracetamol, the active ingredient in Paracetamol/Codeína Kern Pharma, is a combination analgesic presented as a tablet for oral use. It treats mild to moderate pain and reduces fever in adult patients. GNH USA supplies Paracetamol/Codeína Kern Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
GNH USA supplies Paracetamol/Codeína Kern Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Paracetamol, Codeine Phosphate Hemihydrate used for?
Paracetamol/Codeine is used in the management of pain and fever through its action on the central nervous system and peripheral pain pathways.
- Mild to moderate acute pain: provides relief when non‑opioid analgesics are insufficient. - Post‑operative pain: helps control discomfort after surgical procedures. - Dental pain: reduces pain associated with dental extractions or procedures. - Fever: lowers elevated body temperature in adults. - Musculoskeletal pain: eases discomfort from strains, sprains and back pain.
What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?
Paracetamol/Codeine may cause a range of adverse reactions, most of which are dose‑dependent and reversible.
Common Side Effects: - Nausea: mild to moderate stomach upset. - Constipation: reduced bowel movements. - Drowsiness: feeling of sleepiness or reduced alertness. - Dizziness: light‑headed sensation. - Dry mouth: reduced salivation. - Sweating: increased perspiration.
Serious or Rare Side Effects: - Respiratory depression: slowed breathing, especially at higher doses. - Hepatotoxicity: liver injury from excessive paracetamol exposure. - Allergic reactions: rash, itching, swelling or anaphylaxis. - Seizures: rare occurrence, often linked to overdose. - Dependence or abuse potential: risk of opioid‑related misuse. - Low blood pressure: hypotension in susceptible individuals.
What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?
Paracetamol/Codeine should be used with caution in specific clinical situations and according to professional guidance.
- Liver disease: avoid or limit use due to risk of hepatotoxicity. - Renal impairment: adjust use as kidney function may affect drug clearance. - Respiratory conditions: monitor for respiratory depression in asthma or COPD. - Concomitant CNS depressants: increased sedation when combined with alcohol or benzodiazepines. - Pregnancy and lactation: use only if clearly needed and prescribed. - Children and adolescents: not recommended for routine use in patients under 18 years. - Store at ambient temperature: keep in original packaging, protect from moisture and heat.
What does Paracetamol, Codeine Phosphate Hemihydrate interact with?
Paracetamol/Codeine can interact with several medicines, altering efficacy or safety.
Major Interactions (Avoid): - MAO inhibitors: risk of severe serotonin syndrome. - Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): reduce conversion of codeine to morphine, decreasing analgesia. - CNS depressants: additive sedation and respiratory depression.
Moderate Interactions (Monitor Closely): - Warfarin: may increase bleeding risk through hepatic enzyme modulation. - Antihistamines: can enhance drowsiness. - Diuretics: may affect renal clearance of paracetamol. - Anticonvulsants: may alter hepatic metabolism of both components.
