GNH USA

Europe — EMA

Paracetamol Codeine Frilab (Paracetamol, Codeine Phosphate Hemihydrate)

GNH USA supplies Paracetamol Codeine Frilab (Paracetamol/codeine), a analgesic and antipyretic for mild to moderate pain and fever.

Paracetamol, Codeine Phosphate Hemihydrate

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What is Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol, the active ingredient in Paracetamol Codeine Frilab, is an analgesic presented as an oral dosage form for oral use. It is combined with codeine phosphate hemihydrate to provide relief of mild to moderate pain and reduce fever in adults.

GNH USA supplies Paracetamol Codeine Frilab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide.

What is Paracetamol, Codeine Phosphate Hemihydrate used for?

Paracetamol Codeine Frilab is used in the management of pain and fever through central analgesic and antipyretic pathways. - Mild to moderate pain: alleviates headache, musculoskeletal and dental discomfort. - Post‑operative pain: reduces pain after minor surgical procedures. - Fever: lowers elevated body temperature associated with infection or inflammation.

What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol Codeine Frilab may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Drowsiness: feeling of sleepiness or reduced alertness. - Constipation: difficulty passing stools. - Dizziness: light‑headed sensation. - Dry mouth: reduced salivation. - Sweating: increased perspiration.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, especially at high doses. - Hepatotoxicity: liver injury from excessive paracetamol exposure. - Allergic reaction: rash, itching, or swelling. - Seizures: rare occurrence in susceptible individuals. - Severe hypotension: marked drop in blood pressure. - Dependence or misuse: potential for opioid‑related dependence.

What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol Codeine Frilab should be used with caution in specific clinical situations. - Liver disease: avoid or limit use due to paracetamol metabolism. - Renal impairment: monitor kidney function when using codeine. - Alcohol consumption: increase risk of hepatotoxicity and sedation. - Elderly patients: lower doses may be required to reduce side‑effect risk. - Concomitant CNS depressants: may enhance drowsiness and respiratory depression. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

What does Paracetamol, Codeine Phosphate Hemihydrate interact with?

Paracetamol Codeine Frilab can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Other opioids: additive respiratory depression. - Benzodiazepines or barbiturates: heightened CNS depression. - Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome.

Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., fluoxetine, quinidine): may reduce codeine conversion to morphine. - Anticoagulants (e.g., warfarin): paracetamol may increase bleeding risk. - Antihistamines: may enhance drowsiness. - Diuretics: possible reduction in renal clearance of codeine.

Frequently asked questions

What is Paracetamol Codeine Frilab used for?+
Paracetamol Codeine Frilab is indicated for the relief of mild to moderate pain such as headache, musculoskeletal or dental pain, and for the reduction of fever. It combines paracetamol’s antipyretic action with codeine’s opioid‑mediated analgesia to provide effective symptom control.
How does paracetamol work in this product?+
Paracetamol acts centrally by inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins involved in pain signaling and temperature regulation. This results in analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.
What is the usual dose of Paracetamol Codeine Frilab?+
The specific dose and dosing interval are determined by the prescribing clinician based on the patient’s age, weight, clinical condition and any concomitant medications. Healthcare professionals should follow local prescribing guidelines and adjust the regimen as needed.
Is Paracetamol Codeine Frilab safe during pregnancy or breastfeeding?+
Safety in pregnancy and lactation has not been fully established. Paracetamol is generally considered low‑risk, but codeine crosses the placenta and may affect the newborn. Use only if the potential benefit outweighs the risk and after consulting a qualified healthcare provider.
How do I order Paracetamol Codeine Frilab from GNH USA?+
Enquiries can be submitted via the product page on gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Paracetamol Codeine Frilab compare with plain paracetamol tablets?+
Plain paracetamol provides analgesic and antipyretic effects but lacks the opioid component. Adding codeine enhances pain relief, especially for moderate pain, but also introduces opioid‑related risks such as sedation, respiratory depression and potential dependence. Choice depends on pain severity and patient risk factors.
What are the storage requirements for Paracetamol Codeine Frilab?+
Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture, direct sunlight and extreme heat to maintain potency and stability throughout its shelf life.
How is Paracetamol Codeine Frilab administered?+
The medication is taken orally, usually with a glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal upset. Patients should follow the dosing instructions provided by their prescriber.
What are the most serious risks associated with Paracetamol Codeine Frilab?+
Serious risks include respiratory depression, especially in opioid‑naïve individuals or when combined with other CNS depressants, hepatotoxicity from excessive paracetamol, severe allergic reactions, and the potential for dependence or misuse of the codeine component.
Who should not use Paracetamol Codeine Frilab?+
Patients with known hypersensitivity to paracetamol, codeine or any excipients, those with severe liver or respiratory disease, individuals taking monoamine oxidase inhibitors, and children under the age limits set by local regulations should avoid this product unless specifically directed by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Laboratoires Frilab
Origin
EU

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