Europe — EMA
Paracetamol + Codeine Apap Us Pharmacia (Paracetamol, Codeine Phosphate Hemihydrate)
GNH USA supplies Paracetamol + Codeine Apap Us Pharmacia (Paracetamol + Codeine), an analgesic combination for moderate to severe pain and fever.
International sale not permitted. Listed for the domestic market and B2B only.
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What is Paracetamol, Codeine Phosphate Hemihydrate?
Paracetamol, the active ingredient in Paracetamol + Codeine Apap Us Pharmacia, is an analgesic combination presented as an oral tablet for systemic use. It provides pain relief and reduces fever in adults and children when prescribed by a qualified healthcare professional.
GNH USA supplies Paracetamol + Codeine Apap Us Pharmacia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Including temperature‑controlled shipping where required.
What is Paracetamol, Codeine Phosphate Hemihydrate used for?
Paracetamol + Codeine is used to manage pain and fever by acting on central pain pathways and thermoregulatory centers.
- Moderate to severe acute pain: provides analgesia when non‑opioid analgesics alone are insufficient. - Post‑operative pain: helps control pain following surgical procedures. - Fever: reduces elevated body temperature when antipyretic effect is needed.
What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?
Paracetamol + Codeine may cause a range of adverse reactions, varying from mild to serious.
Common Side Effects: - Nausea - Constipation - Drowsiness - Dizziness - Vomiting - Dry mouth
Serious or Rare Side Effects: - Respiratory depression - Severe allergic reactions (e.g., rash, angioedema) - Hepatotoxicity, especially with high paracetamol doses - Seizures - Hypotension - Dependence or addiction potential
What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?
When prescribing or dispensing Paracetamol + Codeine, consider the following precautions to ensure safe use.
- Liver function assessment: avoid use in patients with severe hepatic impairment or chronic alcohol abuse. - Alcohol avoidance: advise patients to limit or abstain from alcohol while taking the product. - Respiratory monitoring: use caution in individuals with asthma or other respiratory disorders. - Elderly caution: start with the lowest effective dose and monitor for sedation or falls. - Concomitant CNS depressants: avoid or closely monitor use with benzodiazepines, antihistamines, or alcohol. - Store at ambient temperature: keep below 25 °C in the original container, protected from moisture and direct sunlight.
What does Paracetamol, Codeine Phosphate Hemihydrate interact with?
Paracetamol + Codeine can interact with several medicines; some combinations should be avoided while others require careful monitoring.
Major Interactions (Avoid): - Other opioids or strong CNS depressants (e.g., benzodiazepines, alcohol) – increased risk of respiratory depression. - Monoamine oxidase inhibitors – may precipitate serotonin syndrome. - CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) – can raise codeine levels and risk toxicity. - Hepatotoxic drugs (e.g., isoniazid, high‑dose acetaminophen) – increase risk of liver injury. - Mixed opioid preparations – may lead to cumulative opioid effects.
Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampicin, carbamazepine) – may reduce analgesic efficacy. - Anticholinergic agents – may worsen constipation. - Diuretics – may enhance hypotensive effects. - NSAIDs – combined use can increase hepatic load. - Antihistamines – may add to sedation.
