GNH USA

Europe — EMA

Paracetamol & Codeine Accord-Uk (Paracetamol, Codeine Phosphate Hemihydrate)

GNH USA supplies Paracetamol & Codeine Accord-Uk (Paracetamol/Codeine), a combination analgesic for pain and fever. Contact us for a quote today now.

Paracetamol, Codeine Phosphate Hemihydrate

International sale not permitted. Listed for the domestic market and B2B only.

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What is Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol and Codeine Phosphate Hemihydrate, the active ingredient in Paracetamol & Codeine Accord-Uk, is a combination analgesic presented as a tablet for oral use. It provides pain relief and reduces fever in adults requiring stronger analgesia than paracetamol alone.

GNH USA supplies Paracetamol & Codeine Accord-Uk as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol, Codeine Phosphate Hemihydrate used for?

Paracetamol & Codeine Accord-Uk is used to manage moderate to severe pain and associated fever across several clinical situations. - Acute postoperative pain: provides stronger analgesia than paracetamol alone, facilitating recovery. - Dental pain: reduces pain intensity after dental procedures. - Musculoskeletal pain: alleviates pain from strains, sprains, and arthritis flares. - Fever: lowers elevated body temperature when analgesic effect is also required.

What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol & Codeine Accord-Uk may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Drowsiness: increased sleepiness or fatigue. - Constipation: reduced bowel movements. - Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, especially at higher doses. - Allergic reactions: rash, itching, swelling, or anaphylaxis.

What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?

Before using Paracetamol & Codeine Accord-Uk, consider the following precautions to ensure safe therapy. - Assess liver function: avoid use in severe hepatic impairment. - Avoid in respiratory disorders: patients with asthma or COPD may experience worsening. - Monitor for dependence: codeine carries risk of opioid tolerance and addiction. - Use cautiously in the elderly: increased sensitivity to sedative effects. - Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

What does Paracetamol, Codeine Phosphate Hemihydrate interact with?

Paracetamol & Codeine Accord-Uk can interact with other medicines; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid): - Other central nervous system depressants (e.g., benzodiazepines, alcohol): may enhance sedation and respiratory depression. - Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): reduce conversion of codeine to morphine, decreasing analgesic effect.

Moderate Interactions (Monitor Closely): - Warfarin: may increase bleeding risk; monitor INR. - Anticholinergic agents: may worsen constipation. - Monoamine oxidase inhibitors: potential for serotonin syndrome when combined with other serotonergic drugs.

Frequently asked questions

What is Paracetamol & Codeine Accord-Uk used for?+
Paracetamol & Codeine Accord-Uk is a prescription‑only combination analgesic indicated for the relief of moderate to severe pain and for the reduction of fever when a stronger effect than paracetamol alone is required.
How does the active ingredient work?+
Paracetamol reduces pain and fever by inhibiting central cyclooxygenase enzymes, lowering prostaglandin production. Codeine phosphate hemihydrate is metabolised to morphine, which activates μ‑opioid receptors in the brain and spinal cord, diminishing the perception of pain.
What is the usual dose of this medication?+
The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, pain severity, and overall health. No fixed dosing regimen is provided here; patients should follow the prescriber’s instructions exactly.
Is Paracetamol & Codeine Accord-Uk safe during pregnancy or breastfeeding?+
Safety in pregnancy and lactation has not been fully established. Healthcare professionals should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing patients.
How do I order Paracetamol & Codeine Accord-Uk from GNH USA?+
Submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does this product compare with other analgesics?+
Compared with non‑opioid analgesics such as ibuprofen, the addition of codeine provides stronger pain relief but introduces opioid‑related risks like dependence and respiratory depression. It is generally chosen when paracetamol or NSAIDs alone are insufficient.
What are the storage and handling requirements?+
Store the tablets at ambient temperature, below 25 °C, in the original packaging. Keep them away from moisture and direct sunlight to maintain potency and prevent degradation.
How is Paracetamol & Codeine Accord-Uk administered?+
The medication is taken orally, usually as a whole tablet with a glass of water. It should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional.
What are the most serious risks associated with this drug?+
The most critical concerns are respiratory depression, especially in high‑dose or opioid‑naïve patients, and the potential for dependence, tolerance and abuse. Severe allergic reactions, such as anaphylaxis, also require immediate medical attention.
Who should not use Paracetamol & Codeine Accord-Uk?+
Patients with known hypersensitivity to paracetamol, codeine or any excipients, those with severe hepatic impairment, uncontrolled respiratory disorders, or a history of opioid addiction should avoid this medication.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Accord-Uk Limited
Origin
EU

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