Paracetamol/Codeine Accord (Paracetamol, Codeine Phosphate Hemihydrate)

Paracetamol, the active ingredient in Paracetamol/Codeine Accord, is an analgesic combination presented as a tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children when appropriate.

GNH USA supplies Paracetamol/Codeine Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Paracetamol/Codeine Accord is used for pain relief within the mixed‑pain pathway targeting both nociceptive and neuropathic components. - Dental pain: provides effective relief of post‑extraction or procedural discomfort. - Musculoskeletal pain: reduces pain from strains, sprains and low‑back episodes. - Post‑operative pain: helps manage moderate pain after minor surgical procedures.

Paracetamol/Codeine Accord may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Drowsiness: transient sleepiness or reduced alertness. - Constipation: reduced bowel movements, often mild. - Dizziness: light‑headed sensation, especially on standing. - Dry mouth: decreased salivation.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, particularly at high doses or in opioid‑naïve patients. - Hepatotoxicity: liver injury from excessive paracetamol exposure. - Allergic reactions: rash, itching, swelling or anaphylaxis. - Dependence or misuse: potential for opioid‑related dependence with prolonged use. - Severe hypotension: marked drop in blood pressure, rarely reported.

Paracetamol/Codeine Accord should be used with caution and according to professional guidance. - Liver function monitoring: assess hepatic health before chronic use. - Opioid tolerance assessment: evaluate risk of dependence before initiating therapy. - Concomitant CNS depressants: avoid combining with alcohol or sedatives. - Pregnancy and lactation: use only if clearly needed and prescribed. - Renal impairment: adjust use in patients with reduced kidney function. - Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Paracetamol/Codeine Accord can interact with several medicines, requiring careful management.

Major Interactions (Avoid): - Other opioid analgesics: increased risk of respiratory depression and sedation. - Benzodiazepines: additive central nervous system depression. - Mono‑Mono‑Mono‑Mono  

Moderate   -