GNH USA

Europe — EMA

Paracetamol / Caffeine Brillpharma (Ireland) (Paracetamol, Caffeine)

GNH USA supplies Paracetamol / Caffeine Brillpharma (Ireland) (Paracetamol, Caffeine), an analgesic and antipyretic for headache, fever and general pain

Paracetamol, Caffeine

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What is Paracetamol, Caffeine?

Paracetamol, Caffeine, the active ingredients in Paracetamol / Caffeine Brillpharma (Ireland), are an analgesic, antipyretic and central nervous system stimulant presented as a tablet for oral use. It provides relief of headache, migraine, fever and general pain in adults and adolescents.

GNH USA supplies Paracetamol / Caffeine Brillpharma (Ireland) as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution through established regulatory frameworks.

What is Paracetamol, Caffeine used for?

Paracetamol/caffeine is indicated for the management of common pain and fever conditions. - Headache: reduces pain intensity and associated discomfort. - Migraine: alleviates migraine headache symptoms. - Fever: lowers elevated body temperature. - General pain relief: provides analgesia for musculoskeletal, dental or postoperative pain.

What are the side effects of Paracetamol, Caffeine?

Paracetamol/caffeine may be associated with the following adverse reactions.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Insomnia: difficulty falling or staying asleep. - Restlessness: feeling of agitation or jitteriness. - Headache: paradoxical worsening of headache.

Serious or Rare Side Effects: - Allergic reactions: rash, pruritus, angioedema, or anaphylaxis. - Liver toxicity: elevated transaminases or hepatic failure, especially with overdose. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

What precautions apply to Paracetamol, Caffeine?

When using Paracetamol/caffeine, consider the following precautions. - Pregnancy: safety not established; use only if clearly needed. - Liver disease: avoid or use with caution due to hepatotoxic risk. - Kidney disease: monitor renal function and adjust use accordingly. - Alcohol consumption: concurrent intake may increase risk of liver injury. - Concurrent paracetamol products: avoid duplicate dosing to prevent overdose. - Store at ambient temperature below 25°C: keep in original pack, protect from moisture.

What does Paracetamol, Caffeine interact with?

Paracetamol/caffeine can interact with several medicines; awareness of major and moderate interactions is important.

Major Interactions (Avoid): - Warfarin: may increase anticoagulant effect and bleeding risk. - Other CNS stimulants (e.g., pseudoephedrine): may amplify stimulant effects. - High‑dose paracetamol with other hepatotoxic drugs (e.g., isoniazid): heightened risk of liver injury. - Carbamazepine or other enzyme‑inducing antiepileptics: may reduce paracetamol efficacy.

Moderate Interactions (Monitor Closely): - Alcohol: can potentiate hepatic toxicity. - Lithium: caffeine may decrease lithium clearance, requiring level monitoring. - Theophylline: caffeine can increase plasma theophylline concentrations.

Frequently asked questions

What is Paracetamol / Caffeine Brillpharma used for?+
Paracetamol / Caffeine Brillpharma is an over‑the‑counter oral tablet that combines paracetamol and caffeine to provide analgesic and antipyretic effects. It is commonly used to relieve headache, migraine, fever and a variety of mild‑to‑moderate pains such as musculoskeletal, dental or postoperative discomfort.
How does paracetamol work in this combination?+
Paracetamol reduces pain and fever by centrally inhibiting cyclooxygenase enzymes, which lowers prostaglandin production in the brain. Caffeine blocks adenosine receptors, stimulating the central nervous system and causing modest vasoconstriction. This caffeine‑mediated stimulation enhances the analgesic effect of paracetamol, leading to faster and sometimes more complete pain relief.
What is the usual dose of Paracetamol / Caffeine Brillpharma?+
The specific dose is determined by a qualified prescriber based on the individual’s age, weight, clinical condition and any concomitant medicines. Healthcare professionals follow local prescribing guidelines for paracetamol‑caffeine combinations, and patients should always follow the dosage instructions provided on the label or by their clinician.
Is Paracetamol / Caffeine Brillpharma safe during pregnancy or breastfeeding?+
Safety data for the combined product in pregnancy and lactation are limited. It should only be used when clearly needed and after a risk‑benefit assessment by a healthcare professional. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative options with their doctor.
How do I order Paracetamol / Caffeine Brillpharma from GNH USA?+
To place an order, visit the product page on gnh-usa.com, enter the required quantity and submit the enquiry form. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does this product compare with standard paracetamol tablets?+
Paracetamol alone provides analgesic and antipyretic effects, but the addition of caffeine can increase the speed and magnitude of pain relief, especially for headache and migraine. Compared with non‑steroidal anti‑inflammatory drugs such as ibuprofen, the combination has a lower risk of gastrointestinal irritation but does not possess anti‑inflammatory activity.
How should Paracetamol / Caffeine Brillpharma be stored and handled?+
Store the tablets at ambient temperature below 25 °C, in their original packaging, and protect them from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. Do not use the product if the packaging is damaged or if the tablets appear discoloured.
How is Paracetamol / Caffeine Brillpharma administered?+
The product is taken orally with a full glass of water. It may be taken with or without food, according to the prescriber’s advice. Swallow the tablet whole; do not crush, chew or split unless specifically instructed by a healthcare professional.
What are the most serious risks associated with this medication?+
Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, liver injury that can progress to hepatic failure, and life‑threatening skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of rash, jaundice, dark urine, persistent nausea or any symptoms of an allergic reaction.
Who should not use Paracetamol / Caffeine Brillpharma?+
The combination should be avoided in individuals with known hypersensitivity to paracetamol, caffeine or any excipients, in patients with severe liver impairment, and in those who are taking other medicines containing paracetamol to avoid accidental overdose. Caution is also advised for people with uncontrolled hypertension, cardiac arrhythmias or certain psychiatric conditions due to the stimulant component.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Caffeine
Route
Oral Use
Manufacturer
Brillpharma (Ireland) Limited
Origin
EU

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