GNH USA

Europe — EMA

Paracetamol Baxter Holding

GNH USA supplies Paracetamol Baxter Holding (Paracetamol), an analgesic and antipyretic for the treatment of pain and fever. Request a quote for supply.

Paracetamol

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What is Paracetamol?

Paracetamol, the active ingredient in Paracetamol Baxter Holding, is an analgesic and antipyretic presented as an intravenous solution for intravenous administration. It provides rapid relief of pain and reduction of fever in adult and pediatric patients when oral routes are unsuitable.

GNH USA supplies Paracetamol Baxter Holding as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance for intravenous analgesic needs. The product conforms to EU pharmacopeial standards and is manufactured under strict GMP conditions.

What is Paracetamol used for?

Paracetamol is an analgesic and antipyretic used to manage pain and fever.

- Pain: provides relief of mild to moderate somatic pain. - Fever: reduces elevated body temperature. - Post‑operative pain: helps control discomfort after surgical procedures. - Dental pain: alleviates pain associated with dental treatments. - Headache: eases tension‑type or migraine‑related headache.

What are the side effects of Paracetamol?

Paracetamol may be associated with a range of adverse reactions, most of which are dose‑related or idiosyncratic.

Common Side Effects: - Nausea - Vomiting - Transient elevation of liver enzymes - Mild skin rash - Injection site pain or phlebitis - Headache

Serious or Rare Side Effects: - Acute liver failure, especially with overdose - Severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome - Blood dyscrasias (e.g., agranulocytosis) - Renal impairment - Severe hypotension with rapid intravenous administration

What precautions apply to Paracetamol?

When using Paracetamol Baxter Holding, several precautions should be observed to minimize risk.

- Assess liver function: avoid in patients with severe hepatic impairment. - Monitor renal function: adjust use in renal insufficiency. - Avoid concurrent use with other hepatotoxic drugs. - Use caution in patients with chronic alcohol use. - Do not exceed recommended infusion rate to prevent hypotension. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Paracetamol interact with?

Paracetamol can interact with other medicines, affecting safety or efficacy.

Major Interactions (Avoid): - Concurrent use with other hepatotoxic agents (e.g., high‑dose acetaminophen, isoniazid). - Strong CYP450 inducers (e.g., rifampicin) that may reduce effectiveness. - Warfarin: may enhance anticoagulant effect. - Alcohol: increases risk of liver injury. - High‑dose IV paracetamol combined with NSAIDs may raise renal risk.

Moderate Interactions (Monitor Closely): - Antiepileptics (e.g., carbamazepine) may alter metabolism. - Certain antibiotics (e.g., fluoroquinolones) may increase hepatotoxic potential. - Oral contraceptives: may slightly affect hepatic enzyme activity. - Antifungals (e.g., ketoconazole) may affect drug metabolism. - Herbal supplements (e.g., St. John’s wort) may induce metabolism.

Frequently asked questions

What is Paracetamol Baxter Holding used for?+
Paracetamol Baxter Holding is an intravenous formulation of paracetamol indicated for the rapid relief of mild to moderate pain and for the reduction of fever. It is commonly used in hospital settings where oral administration is not feasible, such as postoperative care, emergency medicine, and in patients who are unable to swallow tablets.
How does Paracetamol work?+
Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, which reduces the synthesis of prostaglandins that mediate pain and regulate body temperature. This central action provides analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.
What is the usual dose of Paracetamol Baxter Holding?+
The specific dose of Paracetamol Baxter Holding is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and overall health status. Healthcare professionals follow local guidelines and product labeling to calculate the appropriate infusion volume and rate for each individual.
Is Paracetamol Baxter Holding safe in pregnancy or breastfeeding?+
Paracetamol Baxter Holding falls under an unknown pregnancy category, and safety data for intravenous use during pregnancy or lactation are limited. Caution is advised, and the product should only be used if the potential benefit justifies any possible risk to the fetus or infant, after consulting a healthcare professional.
How do I order Paracetamol Baxter Holding from GNH USA?+
To order Paracetamol Baxter Holding, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and the necessary import documentation.
How does Paracetamol Baxter Holding compare with the main alternative drug or class?+
The primary alternative to intravenous paracetamol is intravenous ibuprofen, which adds anti‑inflammatory activity but carries a higher risk of gastrointestinal and renal side effects. Paracetamol offers a more favorable safety profile for hepatic and renal function when used at recommended doses, making it a preferred choice for patients where anti‑inflammatory effects are not required.
How should Paracetamol Baxter Holding be stored and handled?+
Paracetamol Baxter Holding should be stored at 2‑8 °C in a refrigerator, protected from light. The container must not be frozen or shaken. Prior to use, inspect the solution for particulate matter or discoloration, and handle it using aseptic techniques to maintain sterility.
How is Paracetamol Baxter Holding administered?+
Paracetamol Baxter Holding is administered intravenously by slow infusion, typically over 15 minutes, using a calibrated infusion set. The exact infusion rate and total volume are prescribed by the treating clinician, who also monitors the patient for any immediate adverse reactions during and after administration.
What are the most serious risks to watch for when using Paracetamol Baxter Holding?+
The most serious risks include acute liver failure, especially in cases of overdose or when combined with other hepatotoxic agents, and severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Rapid infusion can also cause hypotension, and rare blood disorders like agranulocytosis have been reported.
Who should not use Paracetamol Baxter Holding?+
Paracetamol Baxter Holding should be avoided in patients with known severe hepatic impairment, a history of hypersensitivity to paracetamol or any component of the formulation, and in those who have experienced serious adverse reactions to previous paracetamol therapy. Caution is also warranted for patients with uncontrolled severe renal disease.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol
Route
Intravenous Use
Manufacturer
Baxter Holding B.V.
Origin
EU

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