GNH USA

Europe — EMA

Paracetamol And Codeine Boots (Paracetamol, Codeine Phosphate)

GNH USA supplies Paracetamol And Codeine Boots (Paracetamol/Codeine Phosphate), a combination analgesic for mild to moderate pain and fever. Request a quote.

Paracetamol, Codeine Phosphate

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What is Paracetamol, Codeine Phosphate?

Paracetamol, the active ingredient in Paracetamol And Codeine Boots, is a combination analgesic presented as an oral tablet formulation for oral use, together with codeine phosphate. It provides analgesic and antipyretic effects for mild to moderate pain and fever in adult patients.

GNH USA supplies Paracetamol And Codeine Boots as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets. The product is manufactured in the European Union and meets EU pharmacopoeial standards.

What is Paracetamol, Codeine Phosphate used for?

Paracetamol and codeine phosphate act as a combination analgesic and antipyretic, addressing pain and fever pathways.

- Mild to moderate pain: provides relief by acting on central pain pathways and opioid receptors. - Fever: reduces elevated body temperature through central COX inhibition. - Post‑operative discomfort: helps manage postoperative pain in adults after surgery.

What are the side effects of Paracetamol, Codeine Phosphate?

Paracetamol and codeine tablets may cause a range of adverse reactions.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Dizziness: transient feeling of light‑headedness. - Drowsiness: increased sleepiness, especially after the first doses. - Constipation: reduced bowel movements. - Vomiting: occasional expulsion of stomach contents. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, potentially life‑threatening. - Dependence or abuse potential: risk of opioid‑related addiction. - Severe allergic reactions: rash, itching, swelling, or anaphylaxis. - Hepatotoxicity: liver injury, particularly with overdose. - Low blood pressure: hypotension in susceptible individuals. - Seizures: rare occurrence, especially with high doses.

What precautions apply to Paracetamol, Codeine Phosphate?

When prescribing or dispensing Paracetamol And Codeine Boots, consider the following precautions.

- Assess liver function: avoid use in patients with severe hepatic impairment. - Monitor for opioid dependence: watch for signs of misuse or addiction. - Avoid concomitant CNS depressants: limit use with benzodiazepines, alcohol, or other sedatives. - Use the lowest effective dose: titrate to pain relief while minimizing exposure. - Pregnancy and breastfeeding: consult a healthcare professional before use. - Store at ambient temperature: keep in the original pack, protect from moisture and heat.

What does Paracetamol, Codeine Phosphate interact with?

Paracetamol and codeine may interact with several medicines; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid): - Other opioid analgesics: additive risk of respiratory depression. - Benzodiazepines or barbiturates: increased central nervous system depression. - Alcohol: enhances sedative and respiratory‑depressant effects.

Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may reduce conversion of codeine to morphine, lowering analgesic effect. - CYP3A4 inducers (e.g., rifampicin, carbamazepine): may decrease paracetamol plasma concentrations. - Anticoagulants (e.g., warfarin): may increase bleeding risk when combined with high‑dose paracetamol.

Frequently asked questions

What is Paracetamol And Codeine Boots used for?+
Paracetamol And Codeine Boots is a prescription‑only oral tablet that combines paracetamol and codeine phosphate to relieve mild to moderate pain and to reduce fever. It is commonly used in adults for conditions such as headache, dental pain, musculoskeletal discomfort, and postoperative pain, as well as for febrile episodes.
How does paracetamol work in this product?+
Paracetamol acts centrally by inhibiting cyclo‑oxygenase enzymes, which lowers prostaglandin synthesis in the brain. This reduces the perception of pain and helps reset the hypothalamic temperature set‑point, producing antipyretic effects. In the combination, codeine phosphate is converted to morphine, which activates µ‑opioid receptors to further enhance analgesia.
What is the usual dose of Paracetamol And Codeine Boots?+
The exact dose and dosing interval are determined by the prescribing clinician based on the individual’s age, weight, severity of pain, and overall health status. Healthcare professionals follow local prescribing guidelines and adjust the regimen to achieve effective pain control while minimizing risk.
Is Paracetamol And Codeine Boots safe in pregnancy or breastfeeding?+
Safety in pregnancy and lactation has not been definitively established. Paracetamol alone is generally considered low risk, but codeine carries potential risks to the fetus and infant, especially with prolonged use. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential benefits and risks with their healthcare provider before using this medication.
How do I order Paracetamol And Codeine Boots from GNH USA?+
To place an enquiry, visit the product page on gnh-usa.com, enter the required quantity, and submit the request form. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.
How does Paracetamol And Codeine Boots compare with other analgesics?+
Compared with non‑opioid analgesics such as ibuprofen, the addition of codeine provides stronger pain relief for moderate intensity pain but introduces opioid‑related risks like dependence and respiratory depression. Unlike pure opioid products, the paracetamol component adds antipyretic activity and may allow lower opioid dosing, balancing efficacy and safety when used appropriately.
What are the storage and handling requirements for this product?+
Paracetamol And Codeine Boots should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, direct sunlight, and excessive heat. Do not use if the packaging is damaged or if tablets appear discoloured.
How is Paracetamol And Codeine Boots administered?+
The medication is supplied as oral tablets. Patients should swallow the tablet whole with a full glass of water, unless otherwise directed by a healthcare professional. It is usually taken with or without food, but taking it with food may reduce gastrointestinal discomfort.
What are the most serious risks to watch for while taking this medication?+
The most serious risks include respiratory depression, especially when combined with other CNS depressants, and the potential for opioid dependence or abuse. Severe allergic reactions such as anaphylaxis, liver injury from excessive paracetamol, and profound hypotension are also critical concerns that require immediate medical attention.
Who should not use Paracetamol And Codeine Boots?+
The product should be avoided in individuals with known hypersensitivity to paracetamol, codeine, or any excipients, in patients with severe hepatic impairment, in children under the age specified by local regulations, and in anyone taking monoamine oxidase inhibitors within 14 days. Caution is also advised for patients with respiratory disorders, a history of substance abuse, or concurrent use of strong CNS depressants.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Codeine Phosphate
Route
Oral Use
Manufacturer
Bristol Laboratories Limited
Origin
EU

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