GNH USA

Europe — EMA

Paracetamol Accord

GNH USA supplies Paracetamol Accord (Paracetamol), an analgesic/antipyretic for pain and fever.

Paracetamol

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What is Paracetamol?

Paracetamol, the active ingredient in Paracetamol Accord, is an analgesic presented as an oral tablet for oral use. It belongs to the analgesic/antipyretic therapeutic class and is available over‑the‑counter across the European market. The drug relieves mild to moderate pain and reduces fever in adults and children when appropriate.

GNH USA supplies Paracetamol Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our global distribution network ensures consistent quality and regulatory compliance for each batch delivered to healthcare providers.

What is Paracetamol used for?

Paracetamol is used to manage pain and fever by acting on the central prostaglandin pathway.

Pain: Provides relief of mild to moderate pain such as headache, toothache, or muscle aches. Fever: Reduces elevated body temperature associated with infections or inflammatory conditions. Cold and flu symptoms: Alleviates discomfort associated with common cold or influenza.

What are the side effects of Paracetamol?

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: Mild gastrointestinal upset that may resolve with continued use. - Rash: Skin redness or mild itching without systemic involvement. - Headache: Transient headache that does not require discontinuation. - Dizziness: Light‑headed sensation, especially in higher doses. - Abdominal discomfort: Mild stomach upset or discomfort.

Serious or Rare Side Effects: - Severe skin reactions: Including Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatotoxicity: Liver injury that can be dose‑related or idiosyncratic. - Blood disorders: Such as agranulocytosis or thrombocytopenia. - Anaphylaxis: Rare systemic allergic reaction requiring immediate medical attention. - Renal impairment: Acute kidney injury in susceptible individuals.

What precautions apply to Paracetamol?

Paracetamol should be used with attention to patient‑specific factors and proper storage.

Assess liver function: Avoid use in patients with severe hepatic impairment. Avoid excessive alcohol: Concomitant intake increases risk of liver injury. Do not exceed recommended daily dose: Overdose may lead to hepatotoxicity. Use with caution in renal impairment: Monitor renal function in at‑risk patients. Pregnancy and breastfeeding: Consult a healthcare professional before use. Store at ambient temperature: Keep in the original pack, protect from moisture.

What does Paracetamol interact with?

Paracetamol can interact with several medicines, requiring awareness of the interaction level.

Major Interactions (Avoid): - Alcohol: Increases risk of hepatotoxicity. - Warfarin: May enhance anticoagulant effect, increasing bleeding risk. - Carbamazepine, phenytoin, rifampicin: Induce metabolism, reducing paracetamol efficacy.

Moderate Interactions (Monitor Closely): - Other hepatotoxic drugs (e.g., isoniazid, valproic acid): May compound liver risk. - CYP2E1 inducers (e.g., smoking): Can affect paracetamol clearance. - High‑dose paracetamol with other analgesics (e.g., NSAIDs): May increase renal impairment risk.

Frequently asked questions

What is Paracetamol Accord used for?+
Paracetamol Accord contains paracetamol, an over‑the‑counter analgesic and antipyretic. It is used to relieve mild to moderate pain such as headache, toothache, muscle aches, and to reduce fever associated with infections or inflammatory conditions.
How does paracetamol work?+
Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, which reduces the production of prostaglandins involved in pain signaling and temperature regulation. This central action provides analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.
What is the usual dose of Paracetamol Accord?+
The appropriate dose of Paracetamol Accord is determined by a qualified prescriber based on the patient’s age, weight, clinical condition, and local regulatory guidelines. Patients should follow the dosage instructions provided by their healthcare professional and not exceed the recommended maximum daily amount.
Is Paracetamol Accord safe during pregnancy or breastfeeding?+
Paracetamol is generally considered the analgesic/antipyretic of choice when treatment is needed during pregnancy or lactation, but safety depends on individual circumstances. Pregnant or breastfeeding individuals should consult their healthcare provider before using Paracetamol Accord to ensure it is appropriate for their situation.
How do I order Paracetamol Accord from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.
How does Paracetamol Accord compare with other analgesics?+
Paracetamol offers analgesic and antipyretic benefits with a lower risk of gastrointestinal irritation compared with non‑steroidal anti‑inflammatory drugs (NSAIDs). Unlike NSAIDs, it has minimal anti‑inflammatory activity and does not affect platelet function, making it a preferred option for patients who need pain relief without the bleeding risk associated with NSAIDs.
What are the storage and handling requirements for Paracetamol Accord?+
Paracetamol Accord should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in areas with high humidity or direct sunlight.
How is Paracetamol Accord administered?+
Paracetamol Accord is administered orally. The tablet should be swallowed whole with water and taken according to the prescriber’s instructions. It can be taken with or without food, but patients should avoid crushing or chewing the tablet unless specifically directed.
What are the most serious risks associated with Paracetamol Accord?+
The most serious risks include dose‑related hepatotoxicity, which can lead to acute liver failure, and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should be vigilant for signs of liver injury (e.g., jaundice, dark urine) or serious skin changes and seek immediate medical attention if they occur.
Who should not use Paracetamol Accord?+
Paracetamol Accord should be avoided in individuals with known hypersensitivity to paracetamol or any excipients in the tablet, in patients with severe hepatic impairment, and in those who have consumed excessive alcohol or other hepatotoxic substances. Consultation with a healthcare professional is essential before use in these populations.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol
Route
Oral Use
Manufacturer
Accord Healthcare B.V.
Origin
EU

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