GNH USA

Europe — EMA

Paracetamol Accord

GNH USA supplies Paracetamol Accord (Paracetamol), an analgesic for pain, fever and postoperative analgesia.

Paracetamol

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What is Paracetamol?

Paracetamol, the active ingredient in Paracetamol Accord, is an analgesic presented as an injectable solution for intravenous use. It provides effective relief of mild to moderate pain, lowers elevated body temperature, and is commonly employed for postoperative analgesia in surgical patients, offering rapid onset of action in acute care environments.

GNH USA supplies Paracetamol Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide, ensuring quality‑assured products that meet European Union regulatory standards and are available for global procurement.

What is Paracetamol used for?

Paracetamol Accord is used in the analgesic and antipyretic pathway to manage pain and fever.

- Pain: Provides analgesia for mild to moderate acute pain. - Fever: Reduces elevated body temperature in febrile states. - Postoperative analgesia: Controls pain following surgical procedures.

What are the side effects of Paracetamol?

Paracetamol Accord may be associated with adverse reactions, which are categorized by frequency.

Common Side Effects: - Nausea: Mild to moderate feeling of sickness. - Vomiting: Involuntary expulsion of stomach contents. - Hypotension: Transient drop in blood pressure after infusion. - Injection site pain: Discomfort at the site of intravenous administration.

Serious or Rare Side Effects: - Anaphylaxis: Severe allergic reaction that can be life‑threatening. - Severe skin reactions: Including Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatic toxicity: Potential liver injury, especially with overdose or pre‑existing liver disease.

What precautions apply to Paracetamol?

When using Paracetamol Accord, consider the following precautions: - Dose adjustment: Use the lowest effective dose and monitor liver function in patients with hepatic impairment. - Renal function: Adjust or avoid in severe renal impairment. - Alcohol use: Limit concurrent alcohol consumption due to increased hepatotoxic risk. - Concomitant hepatotoxic drugs: Avoid or monitor when used with other liver‑affecting medicines. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Paracetamol interact with?

Paracetamol Accord can interact with other medicines; interactions are grouped by clinical significance.

Major Interactions (Avoid): - Warfarin: May increase anticoagulant effect and bleeding risk. - Alcohol: Potentiates hepatotoxicity. - Carbamazepine: Induces metabolism, reducing efficacy.

Moderate Interactions (Monitor Closely): - Isoniazid: May increase risk of liver injury. - Phenobarbital: May lower plasma levels of paracetamol. - Enzyme inhibitors (e.g., fluconazole): May raise paracetamol concentrations.

Frequently asked questions

What is Paracetamol Accord used for?+
Paracetamol Accord is an intravenous formulation of paracetamol indicated for the relief of mild to moderate pain, reduction of fever, and management of postoperative analgesia in hospital settings. It is administered by healthcare professionals to achieve rapid symptom control in acute care environments.
How does paracetamol work?+
Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, which reduces the production of prostaglandins that mediate pain and fever. This central inhibition lowers the perception of pain and resets the hypothalamic temperature set‑point, providing analgesic and antipyretic effects.
What determines the dose of Paracetamol Accord?+
The dose of Paracetamol Accord is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and severity of pain or fever. Healthcare providers follow local guidelines and consider liver and kidney function when selecting the appropriate dosage regimen.
Is Paracetamol Accord safe during pregnancy or breastfeeding?+
Safety data for intravenous paracetamol in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and may prefer alternative therapies unless the expected benefit justifies use. Consultation with a maternal‑fetal medicine specialist is recommended.
How do I order Paracetamol Accord from GNH USA?+
To order Paracetamol Accord, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.
How does Paracetamol Accord compare with other IV analgesics?+
Paracetamol Accord offers analgesic and antipyretic effects with a favorable safety profile compared with opioid‑based IV analgesics, which carry higher risks of respiratory depression and dependence. Unlike non‑steroidal anti‑inflammatory drugs, it has minimal impact on platelet function and gastric mucosa, making it suitable for patients where NSAIDs are contraindicated.
What are the storage requirements for Paracetamol Accord?+
Paracetamol Accord must be stored at 2‑8 °C in a refrigerator. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside the recommended range.
How is Paracetamol Accord administered?+
Paracetamol Accord is administered intravenously by a qualified healthcare professional. The solution is typically diluted in a compatible IV fluid and infused over a short period, usually 15 minutes, to achieve rapid analgesic and antipyretic effects. Administration guidelines are provided in the product’s prescribing information.
What are the most serious risks associated with Paracetamol Accord?+
The most serious risks include severe allergic reactions such as anaphylaxis, life‑threatening skin disorders like Stevens‑Johnson syndrome, and acute liver injury, especially in cases of overdose or pre‑existing hepatic disease. Prompt recognition and medical intervention are essential if any of these reactions occur.
Who should not receive Paracetamol Accord?+
Paracetamol Accord should be avoided in patients with known hypersensitivity to paracetamol or any excipients in the formulation, those with severe hepatic impairment, and individuals who have experienced severe reactions to other paracetamol preparations. Caution is also advised for patients with significant renal dysfunction.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol
Route
Intravenous Use
Manufacturer
Accord Healthcare Polska Sp. Z O.O.
Origin
EU

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