GNH USA

Europe — EMA

Paracetamol

GNH USA supplies Paracetamol (Paracetamol), an Analgesic; Antipyretic for moderate pain and fever.

Paracetamol

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What is Paracetamol?

Paracetamol, the active ingredient in Paracetamol, is an Analgesic; Antipyretic presented as an oral dosage form for oral use. It relieves mild to moderate pain and reduces fever in adults and children.

GNH USA supplies Paracetamol as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol used for?

Paracetamol is used to manage pain and fever by acting on the prostaglandin pathway.

Headache: provides relief from tension‑type or mild migraine headache Musculoskeletal pain: reduces discomfort from strains, sprains, or back pain Fever: lowers elevated body temperature associated with infections or inflammatory conditions

What are the side effects of Paracetamol?

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea or mild stomach discomfort - Transient skin rash or itching - Headache - Dizziness - Elevated liver enzymes (asymptomatic)

Serious or Rare Side Effects: - Hepatotoxicity, especially with overdose or chronic high‑dose use - Severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis - Blood disorders including thrombocytopenia or neutropenia - Anaphylactic or anaphylactoid reactions - Acute renal failure in rare cases

What precautions apply to Paracetamol?

Paracetamol should be used with awareness of specific safety considerations. - Dosage adjustment: assess liver function before initiating therapy in patients with hepatic impairment - Alcohol consumption: avoid excessive alcohol to reduce risk of liver injury - Existing liver disease: use only under medical supervision - Concomitant drugs: monitor for additive hepatotoxic potential with other medications - Pregnancy and breastfeeding: consult a healthcare professional before use - Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight

What does Paracetamol interact with?

Paracetamol can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid): - Concurrent use with other paracetamol‑containing products: risk of overdose - Strong CYP450 inducers (e.g., rifampicin): may reduce analgesic efficacy - Warfarin: may potentiate anticoagulant effect and increase bleeding risk

Moderate Interactions (Monitor Closely): - Alcohol: may amplify hepatotoxic potential - Isoniazid: combined use can increase liver injury risk - Antiepileptics such as carbamazepine: may alter paracetamol metabolism

Frequently asked questions

What conditions is Paracetamol used for?+
Paracetamol is indicated for the relief of mild to moderate pain such as headache, toothache, musculoskeletal discomfort, and for the reduction of fever associated with common infections or inflammatory conditions.
How does Paracetamol work in the body?+
Paracetamol works by inhibiting central cyclooxygenase enzymes, which reduces the synthesis of prostaglandins in the brain. This action lowers the perception of pain and resets the hypothalamic temperature set‑point, producing analgesic and antipyretic effects.
What is the usual dose of Paracetamol?+
The appropriate dose of Paracetamol is determined by a qualified prescriber based on the patient’s age, weight, clinical condition, and any existing medical factors. Patients should follow the specific instructions provided by their healthcare professional.
Is Paracetamol safe during pregnancy or breastfeeding?+
Paracetamol is generally considered compatible with pregnancy and lactation when used at recommended doses, but a healthcare professional should evaluate each case. Women who are pregnant or nursing should discuss use with their physician before starting therapy.
How do I order Paracetamol from GNH USA?+
To place an order, submit an enquiry on the Paracetamol product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.
How does Paracetamol compare with other pain‑relief options?+
Compared with non‑steroidal anti‑inflammatory drugs (NSAIDs), Paracetamol offers analgesic and antipyretic benefits without significant anti‑inflammatory activity or gastrointestinal irritation. It is often preferred when NSAIDs are contraindicated, such as in patients with ulcer disease or renal impairment.
What are the recommended storage conditions for Paracetamol?+
Paracetamol should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and sources of heat to maintain its stability and potency.
How is Paracetamol administered?+
Paracetamol is administered orally, typically as a tablet, capsule, or liquid formulation. The medication should be swallowed with water or, for liquid forms, measured with a calibrated device. Administration follows the dosage prescribed by the treating clinician.
What are the most serious risks associated with Paracetamol?+
The most serious risk is hepatotoxicity, which can occur with overdose or chronic high‑dose use, potentially leading to liver failure. Rare but severe reactions include Stevens‑Johnson syndrome, toxic epidermal necrolysis, and anaphylaxis. Prompt medical attention is required if any serious symptoms develop.
Who should avoid using Paracetamol?+
Paracetamol should be avoided or used with caution in individuals with known severe liver disease, hypersensitivity to the drug, or those who are concurrently taking other paracetamol‑containing products. Patients with a history of severe skin reactions or certain blood disorders should also discuss use with their physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol
Route
Oral Use
Manufacturer
Activase Pharmaceuticals Limited
Origin
EU

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