GNH USA

Europe — EMA

Paracetamol

GNH USA supplies Paracetamol (Acetaminophen), a Analgesic/Antipyretic indicated for pain relief and fever reduction in adults and children.

Paracetamol

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What is Paracetamol?

Paracetamol, the active ingredient in Paracetamol, is an Analgesic presented as a tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children.

GNH USA supplies Paracetamol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol used for?

Paracetamol is used to manage pain and fever across several common conditions.

- Headache: provides relief of mild to moderate tension‑type headache. - Fever: reduces elevated body temperature associated with infections. - Musculoskeletal pain: alleviates aches from strains, sprains and osteoarthritis.

What are the side effects of Paracetamol?

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Headache: occasional worsening of existing headache. - Skin rash: transient erythematous eruptions. - Abdominal discomfort: mild stomach pain.

Serious or Rare Side Effects: - Hepatotoxicity: severe liver injury, especially with overdose. - Stevens‑Johnson syndrome: rare severe skin reaction. - Anaphylaxis: acute allergic response requiring emergency care. - Blood disorders: thrombocytopenia or neutropenia in rare cases.

What precautions apply to Paracetamol?

Paracetamol should be used with awareness of specific safety considerations.

- Liver disease: avoid or use with caution in patients with hepatic impairment. - Alcohol consumption: limit intake to reduce risk of hepatotoxicity. - Pregnancy: consult a healthcare professional; generally avoided in the third trimester. - Age: dose adjustments may be required for children and the elderly. - Drug interactions: review concomitant medications for potential interactions. - Store at ambient temperature: keep in the original pack, protect from moisture and heat.

What does Paracetamol interact with?

Paracetamol may interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid): - Warfarin: increased anticoagulant effect, monitor INR closely. - Isoniazid: heightened risk of liver toxicity. - Alcohol: additive hepatotoxic potential.

Moderate Interactions (Monitor Closely): - Carbamazepine: may reduce paracetamol efficacy. - Phenobarbital: may increase metabolism, lowering plasma levels. - Phenytoin: may enhance hepatic clearance of paracetamol.

Frequently asked questions

What is Paracetamol used for?+
Paracetamol is an over‑the‑counter analgesic and antipyretic used to relieve mild to moderate pain such as headache, toothache, muscle aches, and to lower fever caused by infections or inflammatory conditions. It is commonly employed in both adult and pediatric populations when a non‑opioid option is appropriate.
How does Paracetamol work?+
Paracetamol works by inhibiting the central cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the production of prostaglandins in the brain and spinal cord. Lower prostaglandin levels diminish pain signaling and reset the hypothalamic set‑point for temperature, resulting in analgesic and antipyretic effects.
What is the usual dose of Paracetamol?+
The exact dose of Paracetamol is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and local guidelines. Adults typically receive 500 mg to 1 g per dose at intervals of 4‑6 hours, not exceeding the maximum daily limit, while pediatric dosing follows weight‑based recommendations.
Is Paracetamol safe during pregnancy or breastfeeding?+
Paracetamol is generally considered safe for short‑term use during pregnancy and lactation when prescribed by a clinician. However, it should be avoided in the third trimester unless specifically advised, and the lowest effective dose should be used. Breastfeeding mothers should also follow medical guidance to ensure infant safety.
How do I order Paracetamol from GNH USA?+
To order Paracetamol, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.
How does Paracetamol compare with ibuprofen?+
Paracetamol and ibuprofen both relieve pain and fever, but they act via different mechanisms. Paracetamol primarily works centrally and has minimal anti‑inflammatory activity, whereas ibuprofen is a non‑steroidal anti‑inflammatory drug (NSAID) that reduces inflammation by inhibiting peripheral COX enzymes. Ibuprofen may cause gastrointestinal irritation, while Paracetamol carries a higher risk of liver toxicity at excessive doses.
How should Paracetamol be stored and handled?+
Paracetamol tablets should be stored at ambient temperature, below 25 °C, in their original container to protect from moisture and light. Keep the product out of reach of children and avoid storing in damp or excessively hot environments, which could affect tablet integrity.
How is Paracetamol administered?+
Paracetamol is administered orally, typically as tablets, capsules, or liquid suspensions. The medication is swallowed with water; for liquid forms, a calibrated measuring device should be used to ensure accurate dosing. It is not intended for injection or topical use.
What are the most serious risks associated with Paracetamol?+
The most serious risk of Paracetamol is hepatotoxicity, which can lead to acute liver failure, especially after overdose or when combined with alcohol or other hepatotoxic drugs. Rare but severe reactions include Stevens‑Johnson syndrome, anaphylaxis, and blood dyscrasias. Prompt medical attention is required if signs of liver injury or allergic reaction appear.
Who should not use Paracetamol?+
Paracetamol should be avoided by individuals with known hypersensitivity to the drug, severe liver disease, or those who have consumed excessive alcohol. It is also contraindicated in patients taking certain medications that markedly increase hepatic risk, such as high‑dose isoniazid, unless closely monitored by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol
Route
Oral Use
Manufacturer
Antibiotice Sa
Origin
EU

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