GNH USA

Europe — EMA

Paracetamol

GNH USA supplies Paracetamol (Paracetamol), a widely used Analgesic for mild to moderate pain such as headache, toothache, musculoskeletal aches, and

Paracetamol

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What is Paracetamol?

Paracetamol, the active ingredient in Paracetamol, is an Analgesic presented as a standard oral tablet for Oral use. It is employed to relieve mild to moderate pain such as headache, toothache, or musculoskeletal discomfort, and to reduce fever in both adults and children over a wide range of common conditions.

GNH USA supplies Paracetamol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

What is Paracetamol used for?

Paracetamol acts as an analgesic and antipyretic, targeting pain and fever pathways.

- Headache: provides rapid relief of pain associated with tension or vascular headaches. - Fever: lowers elevated body temperature by acting on the hypothalamic heat‑regulation center. - Dental pain: reduces discomfort following tooth extraction or dental procedures. - Musculoskeletal pain: alleviates aches from sprains, strains, or arthritis. - Cold/flu symptoms: eases general body aches and fever accompanying viral infections.

What are the side effects of Paracetamol?

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: occasional upset stomach or feeling of queasiness. - Skin rash: mild erythema or itching at the site of contact. - Sweating: increased perspiration without exertion. - Dizziness: transient light‑headedness, especially after rapid dose changes. - Elevated liver enzymes: mild, reversible changes detected in routine labs.

Serious or Rare Side Effects: - Stevens‑Johnson syndrome: severe skin blistering requiring immediate medical attention. - Anaphylaxis: rapid onset of breathing difficulty, swelling, and hypotension. - Hepatotoxicity: potentially fatal liver injury, especially with overdose. - Blood disorders: rare cases of agranulocytosis or thrombocytopenia. - Renal impairment: acute kidney injury in susceptible individuals.

What precautions apply to Paracetamol?

Paracetamol should be used with caution in specific populations and clinical situations.

- Dose adjustment: required in patients with hepatic impairment to avoid toxicity. - Alcohol consumption: limit intake, as combined use increases risk of liver damage. - Age: use with caution in children under two years; pediatric dosing must be prescribed. - Concurrent medications: avoid combining with other hepatotoxic drugs without medical guidance. - Pregnancy and lactation: consult a healthcare professional before use. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

What does Paracetamol interact with?

Paracetamol can interact with several medicines, influencing efficacy or safety.

Major Interactions (Avoid): - Warfarin: increased anticoagulant effect may lead to bleeding. - Isoniazid: combined use can potentiate hepatotoxicity. - High‑dose acetaminophen combinations: risk of cumulative overdose.

Moderate Interactions (Monitor Closely): - Alcohol: additive liver stress requires monitoring of liver function. - Carbamazepine: may reduce analgesic effect by increasing metabolism. - Phenobarbital: may increase drug clearance, lowering therapeutic benefit.

Frequently asked questions

What conditions is Paracetamol used to treat?+
Paracetamol is used to relieve mild to moderate pain such as headache, toothache, musculoskeletal aches, and to reduce fever. It is commonly employed for common cold or flu symptoms, menstrual cramps, and postoperative discomfort, providing symptomatic relief without significant anti‑inflammatory activity.
How does Paracetamol work in the body?+
Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, which reduces the production of prostaglandins that signal pain and regulate body temperature. This central action raises the pain threshold and resets the hypothalamic set‑point for temperature, resulting in analgesic and antipyretic effects.
What is the usual dose of Paracetamol?+
The appropriate dose of Paracetamol is determined by a prescriber based on the patient’s age, weight, clinical condition, and liver function. Healthcare professionals calculate the dosage to ensure efficacy while minimizing the risk of hepatotoxicity, especially in vulnerable populations.
Is Paracetamol safe to use during pregnancy or breastfeeding?+
Paracetamol is generally considered compatible with pregnancy and lactation when used at the lowest effective dose for the shortest duration. However, pregnant or nursing individuals should consult their healthcare provider before starting therapy to confirm that benefits outweigh any potential risks.
How do I order Paracetamol from GNH USA?+
To order Paracetamol, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.
How does Paracetamol compare with ibuprofen?+
Paracetamol provides analgesic and antipyretic effects without significant anti‑inflammatory activity, whereas ibuprofen is a non‑steroidal anti‑inflammatory drug (NSAID) that also reduces inflammation. Paracetamol is generally gentler on the stomach and does not affect platelet function, making it preferable for patients with gastric sensitivity or bleeding risk.
What are the recommended storage conditions for Paracetamol?+
Paracetamol should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and sources of heat to maintain stability and potency throughout its shelf life.
How is Paracetamol administered?+
Paracetamol is administered orally, typically as a tablet, capsule, or liquid suspension. The dose is taken with or without food, and the tablet should be swallowed whole with water unless otherwise directed by a healthcare professional.
What are the most serious risks associated with Paracetamol?+
The most serious risk of Paracetamol is hepatotoxicity, which can lead to acute liver failure, especially with overdose or in patients with pre‑existing liver disease. Rare but severe reactions include Stevens‑Johnson syndrome, anaphylaxis, and blood dyscrasias, all of which require immediate medical attention.
Who should not use Paracetamol?+
Paracetamol should be avoided in individuals with known hypersensitivity to the drug, severe liver impairment, or those who have experienced serious adverse reactions such as Stevens‑Johnson syndrome. Patients taking other hepatotoxic medications should also consult a healthcare professional before use.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol
Route
Oral Use
Manufacturer
Pxg Pharma Gmbh
Origin
EU

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