Paracetamol

Paracetamol, the active ingredient in Paracetamol, is an analgesic and antipyretic presented as a standard oral dosage form for oral use. It relieves mild to moderate pain and reduces fever in adults and children when directed by a healthcare professional.

GNH USA supplies Paracetamol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU quality standards and is manufactured under GMP conditions.

Paracetamol acts on the central pain and temperature pathways to provide symptomatic relief. - Pain: alleviates mild to moderate acute or chronic pain such as headache, dental or musculoskeletal discomfort. - Fever: lowers elevated body temperature associated with infection or inflammatory conditions. - Headache: reduces the intensity of tension‑type or migraine‑related headache. - Osteoarthritis: helps manage pain associated with osteoarthritic joints.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild stomach upset experienced by some users. - Rash: transient skin redness or itching. - Abdominal discomfort: mild stomach pain or dyspepsia. - Headache: occasional worsening of head pain. - Dizziness: brief sensation of light‑headedness. - Sweating: increased perspiration without exertion.

Serious or Rare Side Effects: - Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention. - Liver toxicity: elevated liver enzymes or hepatic failure, especially with overdose. - Blood disorders: rare cases of agranulocytosis or thrombocytopenia. - Anaphylaxis: life‑threatening allergic reaction. - Severe skin reactions: toxic epidermal necrolysis. - Blood dyscrasias: rare hemolytic anemia.

Paracetamol should be used with attention to specific safety considerations. - Dosage adjustment: reduce dose in patients with hepatic impairment. - Alcohol consumption: avoid excessive alcohol to reduce liver risk. - Age considerations: use pediatric formulations for children and monitor elderly patients. - Pregnancy: consult a healthcare professional before use during pregnancy. - Drug interactions: review all concomitant medications for potential interactions. - Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Paracetamol can interact with several medicines, requiring careful management.

Major Interactions (Avoid): - Warfarin: increased risk of bleeding. - Isoniazid: heightened potential for hepatotoxicity. - Carbamazepine: reduced analgesic efficacy.

Moderate Interactions (Monitor Closely): - Alcohol: additive liver toxicity risk. - Other hepatotoxic drugs: monitor liver function tests. - Phenobarbital: may increase paracetamol metabolism, lowering effectiveness.