GNH USA

Europe — EMA

Paracetamol

GNH USA supplies Paracetamol (Paracetamol), a analgesic/antipyretic for pain and fever. Request a quote for global supply. Meets EU standards and testing.

Paracetamol

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What is Paracetamol?

Paracetamol, the active ingredient in Paracetamol, is an Analgesic presented as an intravenous solution for intravenous use. It reduces pain and fever in adults and children when administered under medical supervision, providing rapid symptom relief in hospital settings and is commonly used in postoperative care and emergency departments.

GNH USA supplies Paracetamol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable logistics across global markets. Our robust quality management system and cold‑chain capabilities support timely delivery to diverse healthcare facilities.

What is Paracetamol used for?

Paracetamol acts as an analgesic and antipyretic, reducing pain and fever through inhibition of prostaglandin synthesis.

- Acute pain: provides rapid relief of moderate to severe pain after surgery or injury. - Fever: lowers elevated body temperature in febrile patients. - Postoperative pain: helps manage pain following surgical procedures.

What are the side effects of Paracetamol?

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild gastrointestinal upset after administration. - Injection site discomfort: transient pain or irritation at the IV site. - Rash: mild skin erythema or itching. - Dizziness: occasional light‑headedness post‑dose. - Elevated liver enzymes: mild, transient increase in hepatic markers.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Stevens‑Johnson syndrome: rare but serious skin reaction. - Hepatic failure: potentially life‑threatening liver injury, especially with overdose. - Severe hypotension: marked drop in blood pressure after rapid IV infusion. - Blood dyscrasias: rare cases of thrombocytopenia or leukopenia.

What precautions apply to Paracetamol?

Paracetamol should be used with caution in specific patient populations and clinical situations.

- Assess liver function: avoid use in patients with severe hepatic impairment. - Monitor renal function: adjust use in patients with significant renal failure. - Avoid concomitant hepatotoxic drugs: limit combined use with other agents that affect the liver. - Use caution in alcohol‑dependent patients: increased risk of liver injury. - Pregnancy and breastfeeding: safety not established; weigh benefits versus potential risks. - Store at ambient temperature: keep in original container, protect from moisture and light.

What does Paracetamol interact with?

Paracetamol may interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid): - Concurrent hepatotoxic drugs: increased risk of liver injury. - Strong CYP450 inducers (e.g., rifampicin): may reduce analgesic efficacy. - High‑dose anticoagulants: potential for enhanced anticoagulant effect.

Moderate Interactions (Monitor Closely): - Alcohol consumption: may augment hepatic toxicity. - Other antipyretics/analgesics: additive effect on liver metabolism. - Warfarin: may modestly increase INR, requiring monitoring.

Frequently asked questions

What is Paracetamol used for?+
Paracetamol is an analgesic and antipyretic used to relieve moderate to severe pain and to reduce fever. It is administered intravenously in hospital settings for rapid symptom control, especially after surgery, in emergency care, or when oral administration is not feasible.
How does Paracetamol work?+
Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, which reduces the production of prostaglandins involved in pain signaling and temperature regulation. This central action lowers the perception of pain and resets the hypothalamic set‑point for body temperature.
What is the usual dose of Paracetamol?+
The appropriate dose of Paracetamol is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and renal or hepatic function. Dosage regimens are individualized and should follow the prescriber’s instructions and local guidelines.
Is Paracetamol safe during pregnancy or breastfeeding?+
Safety data for intravenous Paracetamol in pregnancy and lactation are limited. Clinicians should evaluate the potential benefits against possible risks before prescribing to pregnant or breastfeeding women, and consider alternative therapies when appropriate.
How do I order Paracetamol from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.
How does Paracetamol compare with other analgesics?+
Paracetamol provides analgesic and antipyretic effects without the anti‑inflammatory activity of NSAIDs. Compared with opioids, it has a lower risk of respiratory depression and dependence. It is often chosen when a non‑opioid, non‑NSAID option is preferred, especially in patients with bleeding risk or gastrointestinal sensitivity.
How should Paracetamol be stored and handled?+
Paracetamol intravenous solution should be stored at ambient temperature, protected from moisture and light, and kept in its original packaging until use. Once opened, it should be used according to the manufacturer’s stability guidelines and discarded if any discoloration or particulate matter is observed.
How is Paracetamol administered?+
Paracetamol is administered intravenously by slow infusion into a vein, typically over 15 minutes, under the supervision of qualified healthcare personnel. The infusion rate and volume are determined by the prescriber and should follow institutional protocols to avoid rapid administration that could cause hypotension.
What are the most serious risks associated with Paracetamol?+
The most serious risks include severe liver injury or hepatic failure, especially with overdose or in patients with pre‑existing liver disease, and rare hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Prompt recognition and discontinuation are essential if these events occur.
Who should not use Paracetamol?+
Paracetamol should be avoided in patients with known severe hepatic impairment, hypersensitivity to paracetamol or its excipients, and in those taking other hepatotoxic medications at high doses. Caution is also advised for individuals with uncontrolled alcohol use or certain metabolic disorders.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol
Route
Intravenous Use
Manufacturer
Laboratoire Aguettant
Origin
EU

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