GNH USA

Europe — EMA

Panotile

GNH USA supplies Panotile (Fludrocortisone, Neomycin, Polymyxin B), a combination ear‑drop formulation for otitis externa and ear canal inflammation.

Fludrocortisone Acetate, Neomycin Sulfate, Polymyxin B Sulfate, Lidocaine Hydrochloride

Request sourcing

1
Pack/s

What is Fludrocortisone Acetate, Neomycin Sulfate, Polymyxin B Sulfate, Lidocaine Hydrochloride?

Fludrocortisone acetate, neomycin sulfate, polymyxin B sulfate and lidocaine hydrochloride, the active ingredients in Panotile, are a combination of corticosteroid, antibiotic and local anesthetic presented as an ear‑drop formulation for auricular use. The product is intended to treat bacterial ear infections, reduce inflammation and relieve pain in the external auditory canal.

GNH USA supplies Panotile as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

What is Fludrocortisone Acetate, Neomycin Sulfate, Polymyxin B Sulfate, Lidocaine Hydrochloride used for?

Panotile is used in the auricular pathway to manage infections and inflammation of the external ear.

- Otitis externa: reduces bacterial load, inflammation and pain in the ear canal. - Acute bacterial otitis media (adjunct): provides topical antimicrobial activity alongside systemic therapy. - Post‑surgical ear care: helps prevent infection and soothe discomfort after ear procedures. - Ear canal dermatitis: alleviates inflammation and itching associated with dermatologic conditions.

What are the side effects of Fludrocortisone Acetate, Neomycin Sulfate, Polymyxin B Sulfate, Lidocaine Hydrochloride?

Topical ear‑drop therapy with Panotile may be associated with local and systemic adverse reactions.

Common Side Effects: - Ear itching or mild irritation: transient sensation at application site. - Temporary hearing changes: mild muffling that resolves after discontinuation. - Local redness: mild erythema of the ear canal.

Serious or Rare Side Effects: - Allergic contact dermatitis: severe rash, swelling or blistering requiring medical attention. - Ototoxicity: rare hearing loss or vestibular dysfunction, particularly with prolonged use. - Systemic toxicity: rare signs of neomycin or polymyxin B absorption such as nephrotoxicity.

What precautions apply to Fludrocortisone Acetate, Neomycin Sulfate, Polymyxin B Sulfate, Lidocaine Hydrochloride?

When using Panotile, observe the following precautions to ensure safety and effectiveness. - Assess allergy: confirm no known hypersensitivity to corticosteroids, neomycin, polymyxin B or lidocaine. - Limit duration: use only for the prescribed period to reduce risk of ototoxicity. - Avoid perforated tympanic membrane: do not apply if eardrum is ruptured unless directed by a clinician. - Pediatric use: exercise caution in children; dosage and duration should be determined by a healthcare professional. - Concomitant ototoxic drugs: monitor closely if patient receives other ototoxic medications. - Store at below 25°C: keep in original container, protect from moisture and direct sunlight.

What does Fludrocortisone Acetate, Neomycin Sulfate, Polymyxin B Sulfate, Lidocaine Hydrochloride interact with?

Panotile may interact with other medicines; consider the following classifications.

Major Interactions (Avoid): - Systemic aminoglycosides: combined ototoxic risk may lead to hearing loss. - Loop diuretics (e.g., furosemide): increased potential for ototoxicity when used together.

Moderate Interactions (Monitor Closely): - Topical corticosteroids: may enhance systemic steroid exposure. - Other otic antibiotics: overlapping antibacterial activity could alter microbiome. - Anticoagulants: neomycin may rarely affect platelet function; monitor bleeding risk.

Frequently asked questions

What is Panotile used for?+
Panotile is a topical ear‑drop preparation indicated for the treatment of bacterial infections of the external ear, such as otitis externa, as well as for reducing inflammation and relieving pain in the ear canal. It may also be used as adjunct therapy after ear surgery or for managing inflammatory skin conditions of the ear.
How does the combination of fludrocortisone, neomycin, polymyxin B and lidocaine work?+
Fludrocortisone provides anti‑inflammatory activity by modulating glucocorticoid receptors, while neomycin and polymyxin B act as antibiotics that inhibit bacterial protein synthesis and disrupt cell membranes. Lidocaine adds rapid local anaesthesia by blocking sodium channels, which together reduce infection, swelling and pain in the ear.
What is the usual dose of Panotile?+
The specific dose and frequency of Panotile are determined by the prescribing clinician based on the severity of the condition, patient age and ear status. Patients should follow the healthcare professional’s instructions and not alter the regimen without medical advice.
Is Panotile safe to use during pregnancy or breastfeeding?+
Safety data for Panotile in pregnancy and lactation are limited. The prescriber should weigh the potential benefits against any possible risks to the fetus or infant. If treatment is essential, it may be used under close medical supervision.
How do I order Panotile from GNH USA?+
To request Panotile, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Panotile compare with other ear‑drop antibiotics?+
Panotile combines a corticosteroid, two antibiotics and a local anaesthetic in a single formulation, offering anti‑inflammatory, antimicrobial and analgesic effects simultaneously. Many alternative ear drops contain only one antibiotic or lack a steroid, which may require additional products to achieve comparable symptom control.
How should Panotile be stored and handled?+
Panotile should be stored at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid freezing. If the solution appears discoloured or contaminated, discard it.
How is Panotile administered?+
Panotile is applied as ear drops directly into the affected ear(s) while the patient’s head is tilted to expose the canal. The prescribed number of drops is instilled, the head is held in position for a few minutes to allow absorption, and the procedure is repeated according to the clinician’s schedule.
What are the most serious risks associated with Panotile?+
Serious risks include allergic contact dermatitis, ototoxicity leading to hearing loss or balance disturbances, and rare systemic toxicity such as nephrotoxicity from absorbed aminoglycosides. Patients should report any severe rash, sudden hearing changes, dizziness or signs of kidney impairment promptly.
Who should not use Panotile?+
Panotile should be avoided in individuals with known hypersensitivity to any of its components, in patients with a perforated tympanic membrane unless specifically directed by a physician, and in those receiving other ototoxic medications without careful monitoring. Pediatric use requires special consideration by a healthcare professional.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Fludrocortisone Acetate, Neomycin Sulfate, Polymyxin B Sulfate, Lidocaine Hydrochloride
Route
Auricular Use
Manufacturer
Zambon Nv
Origin
EU