Panodil (Paracetamol)

Paracetamol, the active ingredient in Panodil, is an Analgesic presented as a 500 mg tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children.

GNH USA supplies Panodil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Paracetamol acts as a centrally acting analgesic and antipyretic, providing relief across a range of common pain and fever conditions. - Fever: reduces elevated body temperature associated with infections or inflammatory states. - Headache: alleviates tension‑type and mild migraine‑related head pain. - Musculoskeletal pain: eases aches from strains, sprains, or arthritis. - Toothache: provides temporary relief of dental pain. - Cold and flu symptoms: helps control fever and discomfort during viral upper‑respiratory infections.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild stomach upset experienced by some users. - Skin rash: occasional mild erythema or itching. - Elevated liver enzymes: transient changes detected in laboratory tests. - Headache: paradoxical headache in rare cases. - Dizziness: brief sensation of light‑headedness.

Serious or Rare Side Effects: - Hepatotoxicity: severe liver injury, especially with overdose or chronic alcohol use. - Stevens‑Johnson syndrome: rare severe skin reaction. - Blood dyscrasias: agranulocytosis or thrombocytopenia. - Hypersensitivity anaphylaxis: life‑threatening allergic response. - Renal impairment: acute kidney injury in susceptible individuals.

Paracetamol should be used with awareness of specific safety considerations. - Liver disease: avoid or limit use in patients with hepatic impairment. - Alcohol consumption: limit intake, as chronic alcohol use increases hepatotoxic risk. - Pregnancy: use only under medical advice, especially in the third trimester. - Pediatric dosing: ensure appropriate dose based on weight and age. - Concomitant medications: review other products containing paracetamol to prevent accidental overdose. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Paracetamol may interact with several medicines, requiring attention to dosage and monitoring.

Major Interactions (Avoid): - Warfarin: increased anticoagulant effect may raise bleeding risk. - Chronic alcohol: synergistic hepatotoxicity can lead to liver damage. - Hepatotoxic drugs (e.g., isoniazid, rifampicin): combined use may exacerbate liver injury.

Moderate Interactions (Monitor Closely): - Oral contraceptives: may slightly reduce efficacy of the contraceptive. - Antiepileptics (e.g., carbamazepine, phenytoin): may enhance metabolism, lowering paracetamol levels. - High‑dose vitamin C: may increase renal clearance, reducing effectiveness. - Certain antivirals (e.g., ritonavir): may alter paracetamol plasma concentrations.