GNH USA

Europe — EMA

Panmigran (Paracetamol, Acetylsalicylic Acid, Caffeine)

GNH USA supplies Panmigran (Paracetamol, Acetylsalicylic Acid, Caffeine), a combination analgesic for headache, migraine and fever.

Paracetamol, Acetylsalicylic Acid, Caffeine

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What is Paracetamol, Acetylsalicylic Acid, Caffeine?

Paracetamol, Acetylsalicylic Acid and Caffeine, the active ingredients in Panmigran, are a combination analgesic/antipyretic presented as a tablet for oral use. They relieve mild to moderate pain and reduce fever in adults. GNH USA supplies Panmigran as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol, Acetylsalicylic Acid, Caffeine used for?

Panmigran, a combination analgesic/antipyretic, is used to manage pain and fever.

- Headache: provides rapid relief of tension‑type headache. - Migraine: helps alleviate acute migraine attacks. - Fever: reduces elevated body temperature. - Dental pain: eases postoperative dental discomfort. - Musculoskeletal pain: mitigates mild to moderate muscle aches.

What are the side effects of Paracetamol, Acetylsalicylic Acid, Caffeine?

Common Side Effects: - Nausea: mild gastrointestinal upset may occur. - Gastric irritation: occasional discomfort in the stomach. - Dizziness: transient light‑headedness reported. - Insomnia: caffeine can interfere with sleep patterns.

Serious or Rare Side Effects: - Gastrointestinal bleeding: risk increased with aspirin component. - Allergic reactions: rash, angioedema, or anaphylaxis in susceptible individuals. - Liver toxicity: high paracetamol exposure may impair hepatic function. - Renal impairment: prolonged use can affect kidney function. - Severe hypersensitivity: including Stevens‑Johnson syndrome.

What precautions apply to Paracetamol, Acetylsalicylic Acid, Caffeine?

Before using Panmigran, consider the following precautions. - Assess liver function: avoid in severe hepatic impairment. - Evaluate bleeding risk: aspirin may increase bleeding tendency. - Monitor asthma: aspirin‑sensitive asthma may be exacerbated. - Use caution in pregnancy: avoid in the third trimester. - Avoid in children with viral infections: risk of Reye syndrome. - Store at ambient temperature: keep in the original pack, protect from moisture.

What does Paracetamol, Acetylsalicylic Acid, Caffeine interact with?

Panmigran may interact with several medicines.

Major Interactions (Avoid): - Warfarin: increased anticoagulant effect and bleeding risk. - Other NSAIDs: additive gastrointestinal toxicity. - SSRIs: heightened risk of bleeding.

Moderate Interactions (Monitor Closely): - Caffeine‑containing products: may amplify stimulant effects. - Diuretics: potential reduction in renal clearance of aspirin. - Methotrexate: aspirin can decrease its excretion, raising toxicity.

Frequently asked questions

What is Panmigran used for?+
Panmigran is a fixed‑dose combination of paracetamol, acetylsalicylic acid and caffeine used to relieve mild to moderate pain such as headache, migraine, dental discomfort, musculoskeletal aches, and to reduce fever in adults.
How does the combination of paracetamol, aspirin and caffeine work?+
Paracetamol reduces pain and fever by centrally inhibiting COX enzymes. Aspirin irreversibly blocks peripheral COX‑1 and COX‑2, decreasing inflammation and platelet aggregation. Caffeine antagonises adenosine receptors, stimulating the central nervous system and enhancing the analgesic effect of the other two ingredients, resulting in faster and stronger symptom relief.
What is the usual dose of Panmigran?+
The appropriate dose of Panmigran is determined by the prescribing healthcare professional based on the patient’s condition, age, weight and clinical response. Patients should follow the prescriber’s instructions and not exceed the recommended amount.
Is Panmigran safe during pregnancy or breastfeeding?+
Panmigran should be used with caution during pregnancy, especially in the third trimester, because aspirin can affect fetal circulation. Breastfeeding mothers should consult a physician, as the components may pass into milk. The prescriber will weigh benefits against potential risks.
How do I order Panmigran from GNH USA?+
To order Panmigran, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Panmigran compare with other analgesics?+
Compared with single‑ingredient products such as paracetamol alone, Panmigran adds aspirin for anti‑inflammatory action and caffeine for enhanced analgesia, often providing faster and more complete pain relief. However, it also carries the combined safety profile of all three ingredients, requiring attention to bleeding risk and caffeine‑related effects.
What are the storage and handling requirements for Panmigran?+
Panmigran tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep out of reach of children and do not use after the expiry date printed on the label.
How is Panmigran administered?+
Panmigran is taken orally, usually with a full glass of water. It can be taken with or without food, but patients with sensitive stomachs may prefer to take it with meals to minimise gastric irritation.
What are the most serious risks associated with Panmigran?+
Serious risks include gastrointestinal bleeding, especially in patients taking other anticoagulants or NSAIDs, severe allergic reactions such as anaphylaxis, and liver toxicity from excessive paracetamol exposure. Patients should seek immediate medical attention if they notice signs of bleeding, rash, or jaundice.
Who should not use Panmigran?+
Panmigran is contraindicated in individuals with known hypersensitivity to paracetamol, aspirin or caffeine, those with active peptic ulcer disease, severe liver or kidney impairment, and in children with viral infections due to the risk of Reye syndrome. Pregnant women in the third trimester should also avoid it unless advised by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Acetylsalicylic Acid, Caffeine
Route
Oral Use
Manufacturer
Haleon Hellas Single Member Societe Anonyme
Origin
EU

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