Pangrol (Amylase, Lipase, Protease)

Amylase, Lipase, Protease, the active ingredients in Pangrol, is a combination of digestive enzymes presented as a mixed‑enzyme oral formulation for gastrointestinal support use. It aids the breakdown of proteins, fats and carbohydrates in patients requiring enzyme supplementation.

GNH USA supplies Pangrol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Pangrol is a mixed‑enzyme product that assists the digestive process in several clinical contexts. - Exocrine pancreatic insufficiency: improves nutrient absorption and reduces steatorrhea. - Cystic fibrosis related pancreatic dysfunction: supports digestion of fats and proteins. - Post‑surgical pancreatic enzyme replacement: aids recovery of digestive function after pancreatic resection. - Chronic pancreatitis chronic pancreacy: helps maintain adequate digestion despite reduced endogenous enzyme output.

Adverse reactions to mixed‑enzyme preparations are generally mild and related to gastrointestinal tolerance.

Common Side Effects: - Nausea: occasional mild nausea after ingestion. - Abdominal discomfort: transient cramping or bloating. - Diarrhea: loose stools in a minority of patients. - Flatulence: increased gas production. - Constipation: occasional reduced bowel movements. - Taste alteration: brief metallic or bitter taste.

Serious or Rare Side Effects: - Allergic reaction: rash, itching, swelling, or anaphylaxis. - Pancreatitis flare: worsening abdominal pain with elevated enzymes. - Severe abdominal pain: persistent or worsening pain requiring medical evaluation. - Respiratory distress: shortness of breath linked to hypersensitivity. - Hypersensitivity colitis: inflammatory bowel symptoms. - Unexplained weight loss: significant loss without other cause.

When using Pangrol, consider the following safety measures: - Dose adjustment: tailor the amount to the individual’s digestive needs and clinical response. - Medical supervision: use under the guidance of a healthcare professional experienced in pancreatic enzyme therapy. - Monitor nutrition: assess weight, stool fat content and vitamin levels regularly. - Contraindications: avoid in patients with known hypersensitivity to any enzyme component. - Drug interactions: review concomitant medications for potential enzyme‑related effects. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Pangrol may influence the absorption or activity of several co‑administered medicines.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce enzyme activity by increasing gastric pH. - Proton pump inhibitors (PPIs): may diminish the effectiveness of lipase.

Moderate Interactions (Monitor Closely): - Oral anticoagulants (e.g., warfarin): enzyme supplementation can alter vitamin K absorption affecting INR. - Antibiotics (tetracycline, quinolones): chelation risk may affect absorption. - Fat‑soluble vitamin supplements (A, D, E, K): may require dose adjustment of enzymes. - Bile acid sequestrants: can bind enzymes and lower their efficacy.