GNH USA

Europe — EMA

Panalgorin (Metamizole Sodium Monohydrate)

GNH USA supplies Panalgorin (Metamizole), an analgesic/antipyretic for pain and fever management. Request a quote for global supply.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole Sodium Monohydrate, the active ingredient in Panalgorin, is an analgesic/antipyretic presented as a tablet for oral use. It is employed to relieve moderate to severe pain and reduce fever in adult patients. GNH USA supplies Panalgorin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH USA supplies Panalgorin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Metamizole is used primarily for pain and fever management across several clinical contexts.

- Post‑operative pain: provides effective analgesia after surgical procedures. - Cancer‑related pain: helps control moderate to severe pain in oncology patients. - High fever: reduces elevated body temperature when other antipyretics are insufficient. - Acute musculoskeletal pain: alleviates pain from sprains, strains and other musculoskeletal injuries. - Renal colic: assists in relieving severe flank pain caused by kidney stones.

What are the side effects of Metamizole Sodium Monohydrate?

Adverse reactions to Metamizole can vary from mild to severe.

Common Side Effects: - Nausea: mild stomach upset or queasiness. - Dizziness: transient light‑headedness or unsteady feeling. - Rash: skin redness or mild itching. - Elevated liver enzymes: mild, reversible changes in liver function tests.

Serious or Rare Side Effects: - Agranulocytosis: a potentially life‑threatening drop in white blood cells. - Severe allergic reactions: including anaphylaxis and angioedema. - Hepatotoxicity: significant liver injury. - Blood dyscrasias: including thrombocytopenia and hemolytic anemia.

What precautions apply to Metamizole Sodium Monohydrate?

Metamizole should be used with caution and under professional supervision.

- Assess blood counts: monitor for agranulocytosis, especially during early therapy. - Evaluate liver function: check enzymes before and during treatment. - Avoid in known hypersensitivity: discontinue if allergic reactions occur. - Use cautiously in renal impairment: adjust based on renal function. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

What does Metamizole Sodium Monohydrate interact with?

Metamizole may interact with several drug classes, requiring attention to dosing and monitoring.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs: heightened gastrointestinal toxicity.

Moderate Interactions (Monitor Closely): - Corticosteroids: may amplify gastrointestinal side effects. - Methotrexate: potential for enhanced toxicity. - Lithium: possible alteration of lithium serum levels.

Frequently asked questions

What is Panalgorin used for?+
Panalgorin contains Metamizole sodium monohydrate, an analgesic and antipyretic used to treat moderate to severe pain and to lower high fever when other treatments are insufficient. It is commonly prescribed in postoperative, cancer‑related, and acute pain settings, as well as for febrile episodes.
How does Metamizole work?+
Metamizole works by inhibiting cyclo‑oxygenase enzymes, which reduces prostaglandin production involved in pain and fever pathways. It also modulates central nervous system mechanisms, possibly affecting opioid receptors and the hypothalamic temperature‑regulating centre, contributing to its analgesic and antipyretic effects.
What is the usual dose of Panalgorin?+
The appropriate dose of Panalgorin is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, age, weight, and renal or hepatic function. Dosage regimens are individualized and should follow local prescribing guidelines.
Is Panalgorin safe during pregnancy or breastfeeding?+
Metamizole is generally avoided during pregnancy, especially in the third trimester, due to limited safety data and potential risks to the fetus. It is also not recommended while breastfeeding because it may pass into breast milk. Consultation with a healthcare professional is essential before use.
How do I order Panalgorin from GNH USA?+
To order Panalgorin, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Panalgorin compare with other analgesics?+
Compared with traditional NSAIDs, Metamizole offers potent analgesic and antipyretic effects with a lower incidence of gastrointestinal irritation but carries a risk of rare blood disorders such as agranulocytosis. Unlike opioids, it does not produce typical opioid‑related respiratory depression.
How should Panalgorin be stored and handled?+
Panalgorin tablets should be stored at temperatures below 25 °C, in their original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children.
How is Panalgorin administered?+
Panalgorin is supplied as oral tablets that are taken by mouth with water. The exact administration schedule, including timing relative to meals, is determined by the prescribing clinician.
What are the most serious risks associated with Panalgorin?+
The most serious risks include agranulocytosis, a severe reduction in white‑blood‑cell count that can lead to life‑threatening infections, and rare cases of severe allergic reactions such as anaphylaxis. Regular blood‑count monitoring is recommended during therapy.
Who should not use Panalgorin?+
Patients with known hypersensitivity to Metamizole or any component of the formulation, those with a history of agranulocytosis, severe liver disease, or significant renal impairment should avoid Panalgorin. It is also contraindicated in pregnancy, especially in the third trimester.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
Pannonpharma Kft.
Origin
EU

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