Panadol Ultra (Paracetamol, Codeine Phosphate Hemihydrate)

Paracetamol, the active ingredient in Panadol Ultra, is a combination analgesic presented as a tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children when appropriate. GNH USA supplies Panadol Ultra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Panadol Ultra combines the analgesic and antipyretic actions of paracetamol with the opioid‑type activity of codeine, addressing pain pathways in several clinical contexts. - Headache: provides relief from tension‑type and migraine‑associated pain. - Dental pain: reduces discomfort after extractions or dental procedures. - Musculoskeletal pain: eases muscle strains, sprains and low‑back pain. - Fever: lowers elevated body temperature in acute febrile illnesses. - Post‑operative pain: helps manage mild to moderate pain following minor surgery.

Side effects associated with the combination of paracetamol and codeine vary in frequency and severity.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Dizziness: transient light‑headedness. - Constipation: reduced bowel movements. - Drowsiness: feeling of sleepiness. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, especially at higher doses. - Hepatotoxicity: liver injury from excess paracetamol. - Allergic reactions: rash, itching, swelling or anaphylaxis. - Seizures: rare convulsive events. - Dependence or misuse potential: risk of opioid‑related dependence.

When using Panadol Ultra, consider the following safety measures: - Liver function monitoring: assess hepatic health before prolonged use. - Alcohol consumption: limit intake to reduce liver risk. - Concomitant CNS depressants: avoid combined sedation. - Pregnancy and lactation: use only if clearly indicated. - Age restrictions: not recommended for children under 12 years without specialist guidance. - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Panadol Ultra may interact with several medicines, requiring careful management.

Major Interactions (Avoid): - Warfarin: increased bleeding risk. - Other opioid‑containing products: additive respiratory depression. - Hepatotoxic drugs: heightened liver toxicity.

Moderate Interactions (Monitor Closely): - Antihistamines: enhanced drowsiness. - Benzodiazepines: increased central nervous system depression. - CYP2D6 inhibitors: altered codeine metabolism.