GNH USA

Europe — EMA

Panadol Ultra (Paracetamol, Caffeine, Codeine Phosphate Hemihydrate)

GNH USA supplies Panadol Ultra (Paracetamol, Caffeine, Codeine), a moderate pain relief and fever reducer for adults. Request a quote for global supply.

Paracetamol, Caffeine, Codeine Phosphate Hemihydrate

International sale not permitted. Listed for the domestic market and B2B only.

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What is Paracetamol, Caffeine, Codeine Phosphate Hemihydrate?

Paracetamol, the active ingredient in Panadol Ultra, is an analgesic/antipyretic presented as a combination tablet for oral use. It treats moderate pain and reduces fever in adults and children when appropriate. GNH USA supplies Panadol Ultra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH USA supplies Panadol Ultra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol, Caffeine, Codeine Phosphate Hemihydrate used for?

Panadol Ultra is an analgesic/antipyretic combination that provides relief across several common pain‑related pathways.

- Headache: alleviates pain and improves daily functioning - Dental pain: reduces discomfort after procedures or infections - Musculoskeletal pain: eases aches from strains, sprains and minor injuries - Fever: lowers elevated body temperature in acute febrile states - Menstrual cramps: diminishes cramping pain and associated discomfort

What are the side effects of Paracetamol, Caffeine, Codeine Phosphate Hemihydrate?

Side effects vary in frequency and severity.

Common Side Effects: - Nausea: mild stomach upset that may resolve without treatment - Dizziness: transient light‑headedness, especially on standing - Insomnia: difficulty falling or staying asleep, linked to caffeine - Constipation: reduced bowel movements, typical of opioid‑type agents - Dry mouth: reduced salivation causing throat discomfort

Serious or Rare Side Effects: - Hepatotoxicity: liver injury from excessive paracetamol exposure - Respiratory depression: slowed breathing, particularly with high opioid doses - Allergic reactions: rash, itching or swelling indicating hypersensitivity - Seizures: rare neurologic events, often linked to overdose - Severe constipation or bowel obstruction: may require medical attention

What precautions apply to Paracetamol, Caffeine, Codeine Phosphate Hemihydrate?

When using Panadol Ultra, consider the following safety measures:

- Dose limits: adhere to maximum daily paracetamol intake to avoid liver damage - Alcohol use: limit consumption as it increases hepatotoxic risk - Pre‑existing liver disease: use only under medical supervision - Opioid sensitivity: monitor for signs of sedation or respiratory changes - Pregnancy and breastfeeding: consult a healthcare professional before use - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight

What does Paracetamol, Caffeine, Codeine Phosphate Hemihydrate interact with?

Panadol Ultra can interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid): - Warfarin: increased bleeding risk due to enhanced anticoagulant effect - Other paracetamol‑containing products: cumulative toxicity risk - CNS depressants: amplified sedation and respiratory depression

Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., fluoxetine) may reduce codeine conversion to morphine - Antacids: may affect absorption of caffeine - Diuretics: potential alteration of electrolyte balance

Frequently asked questions

What is Panadol Ultra used for?+
Panadol Ultra is a combination analgesic containing paracetamol, caffeine and codeine. It is indicated for the relief of moderate pain such as headache, dental pain, musculoskeletal aches, fever and menstrual‑related discomfort when prescribed by a healthcare professional.
How does paracetamol work in Panadol Ultra?+
Paracetamol reduces pain and fever by inhibiting central cyclooxygenase enzymes, which lowers prostaglandin production in the brain. Caffeine enhances this effect by blocking adenosine receptors, while codeine is converted to morphine and activates opioid μ‑receptors for additional pain control.
What is the usual dose of Panadol Ultra?+
The appropriate dose of Panadol Ultra is determined by the prescribing clinician based on the patient’s age, weight, pain severity and overall health status. Patients should follow the prescriber’s instructions and never exceed the recommended maximum daily amount of paracetamol.
Is Panadol Ultra safe during pregnancy or breastfeeding?+
Use of Panadol Ultra during pregnancy or lactation should only occur under medical advice. Paracetamol is generally considered low‑risk, but codeine crosses the placenta and enters breast milk, so a healthcare professional must evaluate the benefit‑risk balance for each individual.
How do I order Panadol Ultra from GNH USA?+
To order, submit an enquiry on the Panadol Ultra product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Panadol Ultra compare with other pain‑relief options?+
Compared with single‑ingredient paracetamol, Panadol Ultra adds caffeine for enhanced analgesia and codeine for opioid‑type pain control, offering stronger relief for moderate pain. It differs from NSAIDs by lacking anti‑inflammatory activity and generally has a lower risk of gastrointestinal irritation.
What are the storage and handling requirements for Panadol Ultra?+
Store Panadol Ultra tablets at temperatures below 25 °C in their original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date printed on the packaging.
How is Panadol Ultra administered?+
Panadol Ultra is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless specifically directed by a healthcare professional.
What are the most serious risks associated with Panadol Ultra?+
Serious risks include liver injury from excessive paracetamol, respiratory depression from codeine, severe allergic reactions and, in rare cases, seizures. Patients should seek immediate medical attention if they notice signs such as jaundice, difficulty breathing, or a rash.
Who should not use Panadol Ultra?+
Panadol Ultra is contraindicated in individuals with known hypersensitivity to paracetamol, caffeine or codeine, those with severe liver impairment, and patients taking other opioid medications without medical supervision. It should also be avoided in children unless specifically prescribed by a qualified clinician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Caffeine, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Haleon Czech Republic S.R.O.
Origin
EU

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