Panadol (Paracetamol)

Paracetamol, the active ingredient in Panadol, is an analgesic presented as a 500 mg tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children. GNH USA supplies Panadol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Panadol is an analgesic and antipyretic that works within the pain‑relief and fever‑reduction pathways. - Headache: provides relief from mild to moderate tension‑type headaches. - Fever: lowers body temperature in febrile episodes. - Musculoskeletal pain: eases aches of the back, muscles and joints. - Dental pain: reduces discomfort following dental procedures. - Common cold symptoms: helps control pain and fever associated with upper respiratory infections.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: occasional mild stomach upset. - Skin rash: transient redness or itching. - Elevated liver enzymes: mild, reversible changes in blood tests.

Serious or Rare Side Effects: - Hepatotoxicity: risk of liver injury with overdose or chronic high‑dose use. - Stevens‑Johnson syndrome: rare severe skin reaction. - Anaphylaxis: extremely rare allergic response requiring immediate medical attention. - Blood disorders: rare cases of thrombocytopenia or neutropenia.

When using Panadol, consider the following safety measures. - Dose limitation: do not exceed the maximum daily amount recommended by a healthcare professional. - Liver health: avoid use in patients with severe hepatic impairment unless directed by a physician. - Alcohol use: limit alcohol consumption as it may increase liver toxicity risk. - Drug interactions: review concomitant medications for potential additive hepatotoxicity. - Pregnancy and breastfeeding: consult a healthcare provider before use. - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Paracetamol may interact with several medicines; monitoring is advised.

Major Interactions (Avoid): - Warfarin: increased anticoagulant effect may raise bleeding risk. - High‑dose ibuprofen or other NSAIDs: combined hepatotoxic potential.

Moderate Interactions (Monitor Closely): - Antiepileptic drugs (e.g., carbamazepine, phenytoin): may reduce paracetamol plasma levels. - Rifampicin: may increase metabolism, lowering efficacy. - Alcohol: enhances risk of liver injury. - HIV protease inhibitors: may alter paracetamol clearance.