Panadol (Paracetamol)

Paracetamol, the active ingredient in Panadol, is an analgesic presented as a 500 mg tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children.

GNH USA supplies Panadol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Panadol is an analgesic and antipyretic that acts on common pain‑related pathways and fever mechanisms. - Headache: provides relief from tension‑type and migraine‑associated pain. - Fever: lowers elevated body temperature in infectious or inflammatory states. - Musculoskeletal pain: eases aches from back strain, sprains and minor arthritis. - Dental pain: reduces discomfort following dental procedures or toothache. - Menstrual discomfort: alleviates cramps and associated lower‑abdominal pain.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild stomach upset may be reported. - Skin rash: occasional mild erythema or itching. - Elevated liver enzymes: transient increase detected in blood tests.

Serious or Rare Side Effects: - Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement. - Toxic hepatitis: liver injury presenting with jaundice and abdominal pain. - Anaphylaxis: rapid onset of breathing difficulty, swelling and hypotension. - Blood disorders: agranulocytosis or thrombocytopenia in rare cases.

When using Panadol, consider the following safety measures: - Dose limitation: do not exceed the maximum daily amount recommended by a healthcare professional. - Liver health: avoid use in patients with severe hepatic impairment or active liver disease. - Alcohol consumption: limit intake as concurrent alcohol use can increase liver toxicity risk. - Drug interactions: review all concurrent medications with a pharmacist or physician. - Pregnancy and lactation: use only if clearly indicated and prescribed by a qualified healthcare provider. - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Paracetamol may interact with several medicines; monitoring is advised.

Major Interactions (Avoid): - Warfarin: may enhance anticoagulant effect and increase bleeding risk. - Disulfiram: can cause heightened sensitivity to alcohol and hepatic stress.

Moderate Interactions (Monitor Closely): - Isoniazid: combined use may raise risk of liver enzyme elevation. - Carbamazepine: may reduce paracetamol plasma levels, lowering efficacy. - Antiepileptic drugs: some may alter metabolism, requiring dose adjustment. - Oral contraceptives: may slightly increase paracetamol clearance. - Rifampicin: accelerates metabolism, potentially decreasing analgesic effect.