Europe — EMA
Panadol Extra Optizorb (Paracetamol, Caffeine)
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What is Paracetamol, Caffeine?
Paracetamol, the active ingredient in Panadol Extra Optizorb, is an analgesic and antipyretic presented as a tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children. GNH USA supplies Panadol Extra Optizorb as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Paracetamol, Caffeine used for?
Panadol Extra Optizorb combines paracetamol and caffeine, acting on pain‑related pathways and central fatigue mechanisms. - Headache: provides rapid relief of tension‑type and migraine‑associated pain. - Fever: lowers elevated body temperature in acute febrile episodes. - Musculoskeletal pain: eases aches from back strain, minor sprains and joint discomfort.
What are the side effects of Paracetamol, Caffeine?
Adverse reactions are generally mild and dose‑dependent.
Common Side Effects: - Nausea: mild stomach upset that usually resolves without treatment. - Insomnia: difficulty falling or staying asleep, linked to caffeine. - Gastric discomfort: mild irritation of the stomach lining. - Headache: paradoxical worsening of headache in a small subset of users. - Dizziness: transient light‑headedness.
Serious or Rare Side Effects: - Hepatotoxicity: risk of liver injury with excessive paracetamol intake. - Allergic reaction: rash, itching, swelling or anaphylaxis in susceptible individuals. - Blood disorders: rare cases of thrombocytopenia or neutropenia. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
What precautions apply to Paracetamol, Caffeine?
When using Panadol Extra Optizorb, consider the following safety measures: - Avoid excessive alcohol: increases risk of liver toxicity. - Monitor liver function: especially in patients with pre‑existing liver disease. - Limit caffeine intake: to prevent insomnia or palpitations. - Use with caution in pregnancy: discuss with a healthcare professional. - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.
What does Paracetamol, Caffeine interact with?
Paracetamol and caffeine have several notable drug interactions.
Major Interactions (Avoid): - Warfarin: may enhance anticoagulant effect and increase bleeding risk. - Antiepileptic drugs (e.g., carbamazepine, phenytoin): can increase paracetamol metabolism, reducing efficacy.
Moderate Interactions (Monitor Closely): - Mono‑mono‑mono‑MMA ". - Alcohol . - MAO‑ inhibitors. - Certain ". - .



